{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:08:21Z","timestamp":1774267701897,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This randomized single\u2010blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty\u2010four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PGE<jats:sub>2<\/jats:sub> levels were determined using radioimmunoassay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant improvements could be found for all clinical variables in both groups over the study period. The mean changes in probing depth obtained by SRP plus chlorhexidine chip were greater than those obtained by the SRP alone group at 3 and 6 months. In the test group, there was also significant gain in clinical attachment level at 6 months. When data were combined from all groups, significant reductions in GCF PGE<jats:sub>2<\/jats:sub> levels and number of microorganisms were noted at all time points. However, in the test group, reduction was greater at 6 months for crevicular PGE<jats:sub>2<\/jats:sub> level and at 3 and 6 months for proportions of spirochetes.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Based on the findings of this study, the chlorhexidine chip reduced GCF PGE<jats:sub>2<\/jats:sub> levels and had positive effects on clinical parameters and subgingival flora when used as adjunctive therapy to SRP in patients with chronic periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2006.050105","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T15:32:59Z","timestamp":1141313579000},"page":"437-443","source":"Crossref","is-referenced-by-count":37,"title":["Effect of a Controlled\u2010Release Chlorhexidine Chip on Clinical and Microbiological Parameters and Prostaglandin E<sub>2<\/sub> Levels in Gingival Crevicular Fluid"],"prefix":"10.1002","volume":"77","author":[{"given":"Tansel","family":"M\u0131zrak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcliz N.","family":"G\u00fcnc\u00fc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feriha","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tansel Ansal","family":"Balc\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclseren Samanc\u0131","family":"Aktar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fikret","family":"\u0130pek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"40","volume-title":"Glossary of Periodontal Terms","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_4_1","first-page":"132","volume-title":"Clinical Periodontology","author":"Haake SK","year":"2002"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"17","article-title":"Systemic medications: Clinical significance in periodontics","volume":"29","author":"Ciancio SG","year":"2002","journal-title":"J Clin Periodontol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb01935.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01328.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1988.tb01011.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00620.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02397.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb01228.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02407.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01651.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.32"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.989"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280114.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01003.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291001.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2004.00506.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072183"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1984.tb01305.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5s.432"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027001041.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02045.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1984.tb01190.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1967.38.6.610"},{"key":"e_1_2_7_28_1","first-page":"229","article-title":"Problems and proposal for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01510.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.256"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.608"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.12s.1052"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1986.57.6.370"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.10.1209"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01639.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.5.405"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01443.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.8.755"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(96)00084-X"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:21:21Z","timestamp":1760883681000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1902\/jop.2006.050105"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050105","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}