{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:46:48Z","timestamp":1761518808157,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,4,1]],"date-time":"2006-04-01T00:00:00Z","timestamp":1143849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This case report seeks to illustrate the clinical consequences of the administration of bisphosphonate therapy to prevent osteopenia secondary to malignancy in one patient.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A 69\u2010year\u2010old white female with a history of breast cancer with metastasis presented with pain in the upper left quadrant and periodontal pocketing of at least 6 mm in each of the four quadrants of the oral cavity. One week following surgery on the lower right region, lingual bone exposure was noted, and several attempts at achieving healing over the course of 15 months proved unsuccessful.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Upon referral to a surgeon at the Louisiana State University Medical Center, New Orleans, Louisiana, a potential causative factor was finally identified. The drug zoledronic acid, a bisphosphonate given for prevention of osteoclastic activity of bone metastasis, secondary to breast cancer, was identified as the possible cause of inhibition of healing, most likely from regional vascular insufficiency. The drug was immediately discontinued. The patient is healing very slowly with the aid of hyperbaric therapy; she has been unable to achieve smoking cessation, which is deterring thorough healing of the exposed bony area on the lower right lingual side.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Physicians and dentists alike must become increasingly aware of impaired oral healing following the use of bisphosphonates given for malignancy\u2010related osteopenia. A dental exam should be performed before bisphosphonate therapy, as recommended for radiation therapy related to malignancy.<\/jats:p>","DOI":"10.1902\/jop.2006.050187","type":"journal-article","created":{"date-parts":[[2006,4,3]],"date-time":"2006-04-03T12:17:31Z","timestamp":1144066651000},"page":"738-743","source":"Crossref","is-referenced-by-count":27,"title":["Oral Post\u2010Surgical Complications Following the Administration of Bisphosphonates Given for Osteopenia Related to Malignancy"],"prefix":"10.1002","volume":"77","author":[{"given":"Kristi M.","family":"Soileau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18651330307"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)92293-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.189703002157"},{"key":"e_1_2_5_5_1","first-page":"111","volume-title":"Bisphosphonate on Bones","author":"Blomen LJMJ","year":"1995"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.19.1.0325"},{"key":"e_1_2_5_7_1","first-page":"2038","article-title":"Long term prevention of skeletal complications of metastatic breast cancer with pamidronate","volume":"16","author":"Hortobagyi GN","journal-title":"J Clin Oncol 1998"},{"issue":"7","key":"e_1_2_5_8_1","first-page":"S41","article-title":"Delayed progression of bone metastases with pamidronate therapy in breast cancer patients: A randomized multi\u2010center phase III trial","volume":"5","author":"Conte PF","year":"1994","journal-title":"Ann Oncol"},{"key":"e_1_2_5_9_1","unstructured":"Clinical pharmacology monograph on alendronate.2005."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90004-14"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.07.029"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1378"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.037"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02966406"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_5_17_1","first-page":"613","article-title":"Suppressed bone turnover by bisphosphonates increases microdamage accumulation and reduces some biochemical properties in the dog rib","volume":"5","author":"Mashiba T","year":"2001","journal-title":"J Bone Miner Res"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900353"},{"issue":"1","key":"e_1_2_5_19_1","first-page":"S101","article-title":"Effects of growth hormone and pamidronate on bone blood flow, bone mineral and IGF\u2010I levels in the rat","volume":"49","author":"Kapitola J","year":"2000","journal-title":"Physiol Res"},{"key":"e_1_2_5_20_1","first-page":"237","article-title":"Effects of pamidronate on bone blood flow in oophorectomized rats","volume":"47","author":"Kapitola J","year":"1998","journal-title":"Physiol Res"},{"key":"e_1_2_5_21_1","first-page":"6538","article-title":"Bisphosphonates inhibit angiogenesis in vitro and testosterone\u2010stimulated vascular regrowth in the ventral prostate in castrated rats","volume":"62","author":"Fournier P","year":"2002","journal-title":"Cancer Res"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:22:00Z","timestamp":1760876520000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1902\/jop.2006.050187"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050187","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}