{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T03:28:45Z","timestamp":1785122925604,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This investigation aimed to: 1) develop a method to obtain reproducible laser Doppler flow readings (LDFRs) at the gingiva of the maxillary front teeth; 2) evaluate regional gingival blood flow (GBF) in healthy gingiva by laser Doppler flowmetry; 3) compare hand\u2010held LDFR (H\u2010LDFR) with splint LDFR (S\u2010LDFR); and 4) monitor changes in GBF in experimental gingivitis (EG) and chronic gingivitis (CG).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The LDFR, gingival index (GI), and plaque index (PI) were measured at 13 gingival sites (teeth #6 to #11) in 10 healthy volunteers (five males and five females), 23 to 34 years of age, over a period of 12.5 \u00b1 3.27 days employing a partial\u2010mouth EG model and in 11 patients (three males and eight females), 20 to 63 years or age, with CG. LDFRs were obtained by S\u2010LDFR or H\u2010LDFR.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> H\u2010LDFRs were significantly higher than S\u2010LDFRs (<jats:italic>P<\/jats:italic> &lt;0.05). All EG subjects developed gingivitis (PI: 2.77 \u00b1 0.23; GI: 1.5 \u00b1 0.53). EG\u2010LDFRs at diseased sites increased slightly but not significantly over the study period. All CG\u2010patients had high plaque and inflammation scores (PI: 2.8 \u00b1 0.2; GI: 1.63 \u00b1 0.78). CG\u2010LDFRs at sites with GI &gt;1 were significantly higher than LDFRs at healthy sites (<jats:italic>P<\/jats:italic> &lt;0.05). CG\u2010LDFRs were significantly higher than EG\u2010LDFRs at sites with a comparable GI (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> LDFRs are positively correlated with the degree of gingival inflammation. GBF demonstrated significant differences in EG and CG. Modifications of the probe are needed to enhance its clinical applicability in clinical research of periodontal diseases.<\/jats:p>","DOI":"10.1902\/jop.2006.050194","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T08:53:03Z","timestamp":1160470383000},"page":"1762-1771","source":"Crossref","is-referenced-by-count":42,"title":["Local Gingival Blood Flow at Healthy and Inflamed Sites Measured by Laser Doppler Flowmetry"],"prefix":"10.1002","volume":"77","author":[{"given":"Christiane","family":"Gleissner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kempski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Peylo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes 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