{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:56:53Z","timestamp":1792699013055,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> In this study, we evaluated the effects of two different regimes of dietary supplementation of omega\u20103 fatty acid on serum levels of interleukin\u20101 beta (IL\u20101\u03b2), osteocalcin (OC), and C\u2010reactive protein (CRP) in experimental periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Experimental periodontitis was induced by repeated injections of <jats:italic>Escherichia coli<\/jats:italic> lipopolysaccharide (LPS). Thirty\u2010nine adult male Sprague\u2010Dawley rats were divided into four study groups as follows: an LPS positive control group; a saline (negative) control group; and two different groups with omega\u20103 fatty acid dietary supplementation, one in which we gave the supplement subsequent to disease induction (TO3) and the other in which the agent was started prior to and continued subsequent to LPS injections (P + TO3). In the TO3 group, omega\u20103 fatty acid administration was performed for 14 days following induction of experimental periodontitis. In the P + TO3 group, omega\u20103 fatty acid was given for 14 days prior to the start of LPS injections and was continued for another 14 days subsequent to the induction of experimental periodontitis. On day 15 of the first LPS injection, serum samples were obtained and rats were sacrificed. Serum samples were analyzed for IL\u20101\u03b2, OC, and CRP concentrations by enzyme\u2010linked immunosorbent assay. Defleshed jaws were analyzed morphometrically for alveolar bone loss. Data were evaluated statistically by non\u2010parametric tests.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> LPS injection resulted in statistically significantly more bone loss compared to the saline control group (<jats:italic>P<\/jats:italic> &lt;0.05). None of the omega\u20103 fatty acid administration groups showed evidence that this fatty acid was effective in preventing LPS\u2010induced alveolar bone loss. TO3 and P + TO3 groups revealed significantly higher IL\u20101\u03b2 and OC levels than the LPS group (<jats:italic>P<\/jats:italic> &lt;0.05). The study groups exhibited no significant differences in the serum CRP levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Omega\u20103 fatty acid administration does not seem to influence circulating levels of CRP. The significantly increased serum OC level observed in both omega\u20103 fatty acid regimes is curious and could have an effect on bone turnover, as could the further significant increase in serum IL\u20101\u03b2, which could counteract any osteoblastic induction by OC through promotion of osteoclast activity. The lack of a therapeutic benefit of omega\u20103 fatty acid in this study, despite the effects on OC and IL\u20101\u03b2, is difficult to explain, and further studies are required to more fully assess the potential role of this fatty acid in periodontal treatment.<\/jats:p>","DOI":"10.1902\/jop.2006.050214","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T23:25:50Z","timestamp":1146698750000},"page":"814-820","source":"Crossref","is-referenced-by-count":22,"title":["Dietary Supplementation of Omega\u20103 Fatty Acid and Circulating Levels of Interleukin\u20101\u03b2, Osteocalcin, and C\u2010Reactive Protein in 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