{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:43Z","timestamp":1791134323547,"version":"4.1.0"},"reference-count":94,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Several local antimicrobial agents, such as a bioabsorbable chlorhexidine chip, have been developed to enhance the outcome of non\u2010surgical periodontal therapy.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Electronic (MEDLINE and Cochrane Oral Health Group Specialized Trials Register) and manual searches were performed to detect studies concerning the use of the chlorhexidine chip as an adjunct to scaling and root planing in the treatment of chronic periodontitis. Only full\u2010text randomized controlled trials published in English up to June 2005 were included.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Five studies were finally selected following independent screening by two reviewers. Due to considerable heterogeneity in study design, a qualitative data analysis was performed. Multicenter studies have indicated significantly higher pocket reductions and clinical attachment gains following a combination of mechanical debridement and repeated chlorhexidine chip administration in comparison to scaling and root planing alone. However, some recent studies failed to confirm the additional value of the chlorhexidine chip. A number of interstudy disparities with respect to methodological quality and study design may account for this lack of accordance.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The clinical and microbiological data currently available on the chlorhexidine chip are limited and conflicting. More research is needed to elucidate the additional value of the chlorhexidine chip when used as an adjunct to scaling and root planing.<\/jats:p>","DOI":"10.1902\/jop.2006.050216","type":"journal-article","created":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T14:53:47Z","timestamp":1139237627000},"page":"257-264","source":"Crossref","is-referenced-by-count":33,"title":["A Systematic Review on the Effects of the Chlorhexidine Chip When Used as an Adjunct to Scaling and Root Planing in the Treatment of Chronic Periodontitis"],"prefix":"10.1002","volume":"77","author":[{"given":"Jan","family":"Cosyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Wyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.11.655"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01315.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb02249.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.12.783"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1978.49.3.119"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.3.159"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00460.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365549109023379"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1992.tb00520.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027002079.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.768"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.8.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1970.tb00696.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1976.tb00061.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.281207.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb01223.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb00934.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1985.tb01390.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb00997.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb01518.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11.1805"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2218494"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb01160.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb01228.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1983.tb00368.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00882.x"},{"key":"e_1_2_7_30_1","unstructured":"1988 Marcel Dekker New York M Friedman D Steinberg P Tyle Sustained release drug delivery devices for local treatment of dental diseases 491 515"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.7.429"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.7.393"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02407.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00871.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01651.x"},{"key":"e_1_2_7_36_1","first-page":"1806","article-title":"Effect of PerioChip treatment on the subgingival microbiota. [Abstract]","volume":"71","author":"Daneshmand N","year":"2000","journal-title":"J Periodontol"},{"key":"e_1_2_7_37_1","first-page":"1083","article-title":"Use of a chlorhexidine chip in periodontal treatment","volume":"80","author":"Grisi DC","year":"2001","journal-title":"J Dent Res"},{"key":"e_1_2_7_38_1","first-page":"80","article-title":"PerioChip for patients on periodontal supportive therapy","author":"Heasman PA","year":"2001","journal-title":"J Dent Res"},{"key":"e_1_2_7_39_1","article-title":"Chlorhexidine chip as an adjunct in the treatment of chronic periodontitis","author":"Cortelli JR","year":"2002","journal-title":"J Dent Res"},{"key":"e_1_2_7_40_1","article-title":"Clinical evaluation of the use of a controlled\u2010release chlorhexidine chip in the treatment of aggressive periodontitis","author":"Duarte FF","year":"2002","journal-title":"J Dent Res"},{"key":"e_1_2_7_41_1","first-page":"419","article-title":"A chlorhexidine sustained release dosage system for the treatment of periodontal disease. [Abstract]","volume":"68","author":"Zafiropoulos GG","year":"1997","journal-title":"J Periodontol"},{"key":"e_1_2_7_42_1","first-page":"427","article-title":"Local delivery of chlorhexidine","volume":"20","author":"Ciancio SG","year":"1999","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.420"},{"key":"e_1_2_7_44_1","first-page":"84","article-title":"Site\u2010specific chlorhexidine: A periodontal alternative","volume":"49","author":"Fowler EB","year":"2001","journal-title":"Gen Dent"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.256"},{"key":"e_1_2_7_46_1","first-page":"325","article-title":"Use of the PerioChip in treating adult periodontitis: An interim report","volume":"21","author":"Stabholz A","year":"2000","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_47_1","first-page":"443","article-title":"The efficacy of the chlorhexidine chip following scaling and root planing (SRP) and compared to SRP alone (in Chinese)","volume":"36","author":"He L","year":"2001","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.6.302"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.11.663"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.7.405"},{"key":"e_1_2_7_51_1","first-page":"493","article-title":"Ultrasonic root cleansing with 0.1% chlorhexidine gluconate as a coolant","volume":"46","author":"Jervoe\u2010Storm PM","year":"1991","journal-title":"Dtsch Zahnarztl Z"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.3.187"},{"key":"e_1_2_7_53_1","first-page":"11","article-title":"Effect of non\u2010surgical periodontal therapy in an undergraduate dental clinic. Results one year following treatment","volume":"20","author":"Vouros I","year":"1992","journal-title":"J Biol Buccale"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00725.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00499.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00801.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb01779.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02358.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02459.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02356.x"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02448.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.1999.140503.x"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.3.307"},{"issue":"4","key":"e_1_2_7_64_1","first-page":"4","article-title":"The supplemental use of antibiotics in periodontal therapy","volume":"20","author":"Walker C","year":"1999","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_65_1","first-page":"19","article-title":"Clinical and bacteriologic response to irrigation with a chlorhexidine solution in the treatment of periodontal pockets","volume":"23","author":"Diallo AS","year":"2000","journal-title":"Odontostomatol Trop"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00174-1"},{"issue":"5","key":"e_1_2_7_67_1","first-page":"15","article-title":"Minocycline microspheres: A complementary medical\u2010mechanical model for the treatment of chronic periodontitis","volume":"23","author":"Paquette DW","year":"2002","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120005631"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2004.01051.x"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.411"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2001.280114.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290611.x"},{"key":"e_1_2_7_73_1","first-page":"1158","article-title":"The time and ease of placement of the chlorhexidine chip local delivery system","volume":"19","author":"MacNeill SR","year":"1998","journal-title":"Compend Contin Educ Dent"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0311"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0091"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.782"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02397.x"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0253"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.608"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.1.32"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01003.x"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.989"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.291001.x"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290307.x"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.2.137"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1970.tb00698.x"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1973.tb02158.x"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.9.521"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(90)90377-5"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200002000-00004"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1995.tb00161.x"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01693.x"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb01696.x"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.4809695"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00609.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:09:40Z","timestamp":1760868580000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":94,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["10.1902\/jop.2006.050216"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050216","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2]]}}}