{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:11:04Z","timestamp":1792656664291,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Cytokine gene polymorphisms may have an impact on the susceptibility to and progression of chronic periodontitis. In this study, we analyzed the \u22121082 interleukin\u201010 (IL\u201010), \u2212308 tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), transforming growth factor\u2010beta 1 (TGF\u2010\u03b21) (codons 10 and 2\u2010), \u2212174IL\u20106, and +874 interferon\u2010gamma (IFN\u2010\u03b3) gene single\u2010nucleotide polymorphisms in a cohort of patients with chronic periodontal disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The diagnosis was made on the basis of standardized clinical and radiographic criteria. A total of 122 adult patients with chronic periodontitis and 114 unrelated, ethnically and age\u2010matched white control subjects were genotyped by a polymerase chain reaction\u2013sequence\u2010specific primer.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The number of individuals carrying the \u2212174IL\u20106 CC genotype was significantly higher in the group of patients than in the control group (odds ratio [OR] = 1.896; 95% confidence interval [CI] = 1.106 to 3.250; <jats:italic>P<\/jats:italic> = 0.0283). The TGF\u2010\u03b21 (codon 25) GG (Arg<jats:sup>25<\/jats:sup>\/Arg<jats:sup>25<\/jats:sup>) genotype was detected more frequently in control subjects than in periodontitis patients (OR = 0.459; 95% CI = 0.230 to 0.920; <jats:italic>P<\/jats:italic> = 0.0421).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The \u2212174IL\u20106 and TGF\u2010\u03b21 (codon 25) single\u2010nucleotide polymorphisms are associated with susceptibility to chronic periodontitis in the population studied.<\/jats:p>","DOI":"10.1902\/jop.2006.050315","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T08:25:32Z","timestamp":1164875132000},"page":"1978-1983","source":"Crossref","is-referenced-by-count":74,"title":["Analysis of Tumor Necrosis Factor\u2010\u03b1, Transforming Growth Factor\u2010\u03b2, Interleukin\u201010, IL\u20106, and Interferon\u2010\u03b3 Gene Polymorphisms in Patients With Chronic Periodontitis"],"prefix":"10.1002","volume":"77","author":[{"given":"Nina","family":"Babel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgy","family":"Cherepnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Babel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Tropmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Dieter","family":"Volk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Reinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310006168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290101.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2001.2260106.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10314"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb01386.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.1.30"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.20016.x"},{"key":"e_1_2_8_9_1","first-page":"456","article-title":"Study on the correlation of cytokine gene polymorphism with chronic periodontitis","volume":"12","author":"Lin L","year":"2003","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00500.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400605"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.11.1509"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.12.1627"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.06.005"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364221"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_17_1","first-page":"6","article-title":"Use of buccal epithelial cells for PCR amplification of large DNA fragments","volume":"18","author":"Trevilatto PC","year":"2000","journal-title":"J Forensic Odontostomatol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(98)80045-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200110270-00019"},{"key":"e_1_2_8_20_1","unstructured":"2\u2010Way Contingency Table Analysis. 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