{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:40:41Z","timestamp":1760920841803,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Members of the matrix metalloproteinase (MMP) family are implicated in the chronic remodeling in periodontal diseases. Therefore, we performed a case\u2010control study to investigate a plausible association between susceptibility to chronic periodontitis (CP) and the polymorphisms in the MMP\u20109 (gelatinase B) gene.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Using polymerase chain reaction with subsequent restriction analyses, MMP\u20109 \u22121562C\/T and R+279Q variants were determined in 304 subjects (169 patients with CP, 76 with a mild to moderate form and 93 with severe generalized CP, and 135 age\u2010 and gender\u2010matched unrelated control subjects).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The distribution of the MMP\u20109 \u22121562C\/T and R+279Q genotypes and alleles did not significantly differ between cases and controls. However, the frequency of the T variant at position \u22121562 was marginally higher in patients with severe disease compared to those with mild to moderate forms (<jats:italic>P<\/jats:italic> &lt;0.05; <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &gt;0.05). In further analysis, the \u22121562T allele was associated with a severe form of CP in men (odds ratio: 3.87; 95% confidence interval: 1.40 to 10.65; <jats:italic>P<\/jats:italic> &lt;0.01 and <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &lt;0.05 for allele; <jats:italic>P<\/jats:italic> &lt;0.05 and <jats:italic>P<\/jats:italic><jats:sub>corr<\/jats:sub> &gt;0.05 for genotype) but not in women.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These findings suggest that genetic polymorphisms of the MMP\u20109 gene are not associated with the susceptibility to CP in the Czech population; however, the promoter variant may influence the severity of the disease in men.<\/jats:p>","DOI":"10.1902\/jop.2006.050347","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T12:54:05Z","timestamp":1162299245000},"page":"1850-1855","source":"Crossref","is-referenced-by-count":36,"title":["Functional Polymorphisms in the Matrix Metalloproteinase\u20109 Gene in Relation to Severity of Chronic Periodontitis"],"prefix":"10.1002","volume":"77","author":[{"given":"Lydie Izakovicova","family":"Holla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonin","family":"Fassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mu\u017e\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Vanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Vasku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374880020020901"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5s.474"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240110.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21491"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200011090-00003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00279-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1788"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4335"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730080201"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00705.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.2.188"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb01814.x"},{"key":"e_1_2_7_14_1","first-page":"281","article-title":"Development 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