{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:33:59Z","timestamp":1769024039007,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Matrix metalloproteinases (MMPs) are related to tissue destruction and remodeling events in periodontal diseases. A single nucleotide polymorphism in the promoter region of human MMP\u20109 gene is associated with the risk of some inflammatory diseases. Therefore, the aim of this study was to investigate the association between MMP\u20109 promoter polymorphism and severe generalized chronic periodontitis in a Turkish population.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Samples of venous blood and DNA were obtained from 70 severe generalized chronic periodontitis patients and 70 healthy subjects. The alleles of the C\/T polymorphism at position \u22121562 in the promoter region of the MMP\u20109 gene were distinguished by cutting with the <jats:italic>Sph<\/jats:italic>I restriction enzyme. Genotype and allele frequencies were calculated, and data were analyzed by the \u03c7<jats:sup>2<\/jats:sup> test.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a significant difference in MMP\u20109 genotypes between chronic periodontitis patients and healthy controls. The odds ratios for the CT genotype and the combination of CT and TT genotypes were 0.4 (95% confidence interval, 0.17 to 0.93; <jats:italic>P<\/jats:italic> = 0.02) and 0.37 (95% confidence interval, 016 to 0.85; <jats:italic>P<\/jats:italic> = 0.01) relative to the subjects with the CC genotype, respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> MMP\u20109 promoter gene polymorphism seems to be associated with severe generalized chronic periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2006.050378","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T22:23:31Z","timestamp":1157063011000},"page":"1510-1514","source":"Crossref","is-referenced-by-count":36,"title":["Association of Matrix Metalloproteinase\u20109 Promoter Gene Polymorphism With Chronic Periodontitis"],"prefix":"10.1002","volume":"77","author":[{"given":"Gonca Cayir","family":"Keles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezgin","family":"Gunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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