{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:08:02Z","timestamp":1780445282507,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Ginigival recession can be successfully treated with coronally positioned flaps. Twelve\u2010month data failed to demonstrate that topical application of enamel matrix derivative (EMD) used in combination with the coronally positioned flap enhances clinical outcomes of the surgical technique used alone. This study was designed to examine the effects of EMD combined with the coronally positioned flap over an 18\u2010month postoperative period.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty patients presenting with Miller Class I or II gingival recessions on single\u2010rooted teeth participated in this parallel\u2010design clinical study. Six weeks after phase I therapy, recession areas were surgically treated with a coronally positioned flap for root coverage. Teeth in the experimental group received EMD treatment of the exposed root, whereas control teeth did not. Clinical parameters evaluated at baseline and 18 months postoperatively included gingival recession, clinical attachment level, probing depth, and the apico\u2010coronal dimension of the keratinized tissue.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared to baseline, 18\u2010month measurements showed a significant reduction in probing depth, gain in attachment level, and decrease in gingival recession for control and experimental groups. When the results of the two treatment groups were compared, the experimental group presented with significantly greater root coverage than the control group (2.66 \u00b1 0.61 mm versus 1.73 \u00b1 0.70 mm, respectively), more gain in clinical attachment than the control group (2.80 \u00b1 0.76 mm versus 2.06 \u00b1 0.70 mm, respectively), and a greater gain in the apico\u2010coronal dimension of the keratinized tissue than the control group (0.13 \u00b1 0.06 mm versus \u22120.06 \u00b1 0.01 mm, respectively).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The results of this study indicate that topical application of EMD is beneficial in augmenting the effects of the coronally positioned flap in terms of amount of root coverage, gain in clinical attachment, and in increasing the apico\u2010coronal dimension of the keratinized tissue.<\/jats:p>","DOI":"10.1902\/jop.2006.050390","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T08:25:32Z","timestamp":1164875132000},"page":"2031-2039","source":"Crossref","is-referenced-by-count":80,"title":["Root Coverage With a Coronally Positioned Flap Used in Combination With Enamel Matrix Derivative: 18\u2010Month Clinical Evaluation"],"prefix":"10.1002","volume":"77","author":[{"given":"Andrea","family":"Pilloni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Paolantonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo M.","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb02273.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1982.53.6.349"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb00964.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.671"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0011-8532(22)00341-X","article-title":"Regenerative and reconstructive periodontal plastic surgery: Mucogingival surgery","volume":"32","author":"Miller PD","year":"1988","journal-title":"Dent Clin N Am"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00278.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.2.269"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.489"},{"key":"e_1_2_7_10_1","first-page":"8","article-title":"A comparative study of free gingival and subepithelial connective tissue grafts","volume":"10","author":"Sbordone L","year":"1988","journal-title":"Periodontal Case Rep"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01184.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.8.779"},{"key":"e_1_2_7_13_1","first-page":"180","article-title":"Management of advanced periodontitis. Part I. Preliminary report of a method of surgical reconstruction","volume":"61","author":"Harvey P","year":"1965","journal-title":"N Z Dent J"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1969.40.2.119"},{"key":"e_1_2_7_15_1","first-page":"22","article-title":"Cosmetic periodontics \u2013 Coronally repositioned pedicle graft","volume":"46","author":"Brustein DD","year":"1970","journal-title":"Dent Surv"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.6.316"},{"key":"e_1_2_7_17_1","first-page":"550","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Wennstr\u00f6m JL","year":"1997"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00253.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00250.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00252.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00248.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00253.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.11.1693"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.5.521"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290106.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1975.tb01721.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.9.1077"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.188"},{"key":"e_1_2_7_30_1","first-page":"269","article-title":"Clinical and histologic evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix derivative (Emdogain): A case report","volume":"20","author":"Rasperini G","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.12.1534"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.11.680"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.4.203"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050390","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:44:39Z","timestamp":1760877879000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1902\/jop.2006.050390"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050390","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}