{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T18:32:09Z","timestamp":1772044329652,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study was to assess treatment responses to dental flossing in twins.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study was a two\u2010treatment, examiner\u2010blind, randomized, parallel group, controlled study. Fifty\u2010one twin pairs between 12 and 21 years of age were randomized to a 2\u2010week supervised and unsupervised treatment regimen consisting of 1) tongue brushing and toothbrushing (TB) and 2) TB + flossing (TB+Fl). Clinical endpoints were gingival bleeding (papillary bleeding score [PBS]) and oral malodor (levels of volatile sulfur compounds [VSC]). Analysis of variance and covariance methodologies were employed to analyze the data.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Baseline average PBS values were 1.352 and 1.342 for the TB+Fl and TB groups, respectively (<jats:italic>P<\/jats:italic> = 0.937). After 2 weeks of treatment, the TB+Fl group had a statistically significant decrease in PBS values of 0.558 (41.5% versus baseline), whereas the TB group showed no improvement from baseline. The change from baseline for the TB+Fl group was superior to that for the TB group (<jats:italic>P<\/jats:italic> &lt;0.001). Similar findings were observed for the number of baseline papillary bleeding sites. Baseline average intraoral halimeter values were 45.91 and 41.75 for the TB+Fl and TB groups, respectively (<jats:italic>P<\/jats:italic> = 0.504). Both treatment regimens demonstrated highly statistically significant reductions in intraoral breath values versus baseline (all <jats:italic>P<\/jats:italic> &lt;0.001), and the difference between treatment groups was not statistically significant (<jats:italic>P<\/jats:italic> = 0.339). Similar findings were found for expired air.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> In a well\u2010matched twin cohort, tongue and toothbrushing plus flossing significantly decreased gingival bleeding after 2 weeks.<\/jats:p>","DOI":"10.1902\/jop.2006.050399","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T10:57:57Z","timestamp":1154516277000},"page":"1386-1391","source":"Crossref","is-referenced-by-count":29,"title":["Assessment of Treatment Responses to Dental Flossing in Twins"],"prefix":"10.1002","volume":"77","author":[{"given":"Aaron","family":"Biesbrock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia M.A.","family":"Corby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Bartizek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea L.","family":"Corby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mania","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.G.","family":"Bretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter A.","family":"Bretz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"The Cochrane Collaboration. Cochrane Center Register of Controlled Clinical Trials. Available at:http:\/\/www.cochrane.org\/reviews\/index.htm. 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