{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T03:29:08Z","timestamp":1766719748203,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:00:00Z","timestamp":1157068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Gingival enlargement frequently occurs in transplant patients receiving immunosuppressive drugs. It was hypothesized that gingival enlargement associated with cyclosporin use results in a disturbance of the homeostatic balance, which is characterized by an increase in the number of fibroblasts and volume of the extracellular matrix. Matrix metalloproteinase (MMP) serves as an initiator of extracellular matrix destruction. The aim of this study was to determine whether there is an association between genotypes of the MMP\u20101 gene and gingival enlargement in kidney transplant patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixty\u2010one unrelated kidney transplant patients with gingival enlargement and 121 control transplant patients without enlargement were enrolled in the study. Six months after transplantation, all patients were given medication, which included cyclosporin A, and gingival enlargement was assessed. MMP\u20101 polymorphism was determined using the polymerase chain reaction\u2013restriction fragment length polymorphism (PCR\u2010RFLP) assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> In kidney transplant patients with gingival enlargement, the mean score of gingival enlargement was 1.42 \u00b1 0.63, whereas in control subjects, it was 0.0. There were no significant differences in the frequency of \u22121607 1G&gt;2G alleles and genotypes between patients with and without gingival enlargement. In all subjects (N = 182) and in patients without gingival enlargement, the genotype distribution met Hardy\u2010Weinberg equilibrium criteria, whereas in patients with gingival enlargement, it was markedly different (<jats:italic>P<\/jats:italic> &lt;0.06). There was a trend for carriers of at least the 1G allele to have an increased risk of gingival enlargement, but the trend was not statistically significant (odds ratio, 2.32; <jats:italic>P<\/jats:italic> &lt;0.073).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> No association between the MMP\u20101 gene polymorphism and gingival enlargement was revealed in kidney transplant patients who were administered cyclosporin A as a principal immunosuppressive agent.<\/jats:p>","DOI":"10.1902\/jop.2006.050409","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T22:23:31Z","timestamp":1157063011000},"page":"1498-1502","source":"Crossref","is-referenced-by-count":7,"title":["Matrix Metalloproteinase\u20101 Gene Polymorphism in Renal Transplant Patients With and Without Gingival Enlargement"],"prefix":"10.1002","volume":"77","author":[{"given":"Mateusz","family":"Kurzawski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Drozdzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Dembowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Pawlik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Banach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Drozdzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.6.548"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.7.671"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1996.tb00207.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.51"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb02072.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200002270-00010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007706.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02487.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035001051.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.11.1313"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)00126-3"},{"key":"e_1_2_7_13_1","first-page":"5321","article-title":"A single nucleotide polymorphism in the matrix metalloproteinase\u20101 promoter creates an ETS binding site and augments transcription","volume":"58","author":"Rutter JL","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300202.x"},{"key":"e_1_2_7_15_1","first-page":"298","article-title":"A fast method for high\u2010quality genomic DNA extraction from whole human blood","volume":"11","author":"Gustincich S","year":"1991","journal-title":"Biotechniques"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcpr.2001.0398"},{"key":"e_1_2_7_17_1","first-page":"7200","article-title":"Potential for the 2G single nucleotide polymorphism in the promoter of matrix metalloproteinase to enhance gene expression in normal stromal cells","volume":"62","author":"Wyatt CA","year":"2002","journal-title":"Cancer Res"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.050409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:57:14Z","timestamp":1760871434000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.050409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1902\/jop.2006.050409"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.050409","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}