{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:41:36Z","timestamp":1760920896256,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The number of transplanted solid organs and life expectancy after transplantation are steadily rising worldwide. Inflammation is widely recognized as playing a pivotal role in transplant rejection, and several studies have shown that serum interleukin\u20106 (IL\u20106) levels can identify individuals who are at greater risk for rejection. Given the known association between IL\u20106 and chronic periodontitis, the aim of our study was to assess the periodontal status of solid\u2010organ transplant subjects compared to systemically healthy controls, to quantify the IL\u20106 levels in the serum and periodontal tissues, and to explore their association.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010seven heart and kidney transplant and 18 systemically healthy age\u2010matched individuals were recruited. Subjects received a complete periodontal examination, and blood and periodontal tissue samples were collected for quantification of IL\u20106 protein and mRNA levels, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Transplant subjects had significantly higher serum IL\u20106 levels and slightly but statistically significantly increased mean probing depths than healthy controls. Multivariable linear regression analysis adjusting for gender, diabetes, smoking, and immunosuppressant dose showed that the mean probing depth, number of missing teeth, and mean percentage of sites with \u22654 mm attachment loss were independent predictors for elevated serum IL\u20106 levels. Transplant subjects with chronic periodontitis had higher mean serum IL\u20106 levels than those without chronic periodontitis, and there was a positive correlation between periodontal IL\u20106 gene expression levels and serum IL\u20106 protein levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Periodontal tissue destruction and local IL\u20106 synthesis are associated with elevated serum IL\u20106 levels in transplant recipients. This may have serious implications in solid\u2010organ transplant deterioration and chronic rejection.<\/jats:p>","DOI":"10.1902\/jop.2006.060014","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T12:54:05Z","timestamp":1162299245000},"page":"1871-1878","source":"Crossref","is-referenced-by-count":20,"title":["Elevated Serum Interleukin\u20106 (IL\u20106) in Solid\u2010Organ Transplant Recipients Is Positively Associated With Tissue Destruction and IL\u20106 Gene Expression in the Periodontium"],"prefix":"10.1002","volume":"77","author":[{"given":"Effie","family":"Ioannidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Burleson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dongari\u2010Bagtzoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.164"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.146"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.36330"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1101.097803"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2749"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000052974.79428.0C"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000051456.68470.C8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(99)70294-2"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1554"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_8_12_1","first-page":"425","article-title":"Systemic inflammation in cardiovascular and periodontal disease: Comparative study","volume":"9","author":"Glurich I","year":"2002","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_8_13_1","unstructured":"Scientific Registry of Transplant Recipients. 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