{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:01:36Z","timestamp":1780376496374,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this clinical and radiological prospective 5\u2010year study was to compare the long\u2010term effectiveness of a bioabsorbable membrane and a bioactive glass in the treatment of intrabony defects in patients with generalized aggressive periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixteen patients (11 women and five men) with generalized aggressive periodontitis were enrolled in the study. The investigations were confined to 1\u2010 to 3\u2010walled intrabony defects with a depth \u22654 mm and with preoperative probing depths (PDs) \u22657 mm. Teeth with furcation involvement were excluded. Twenty\u2010two of the defects were treated with the membrane (RXT group) and 20 with the bioactive glass (PG group). Allocation to the two groups was randomized. The clinical parameters plaque index (PI), gingival index (GI), PD, bleeding on probing (BOP), gingival recession (GR), clinical attachment level (CAL), and tooth mobility were recorded before surgery and at 6 months and every year for 5 years after surgery. Intraoral radiographs were taken using a standardized paralleling technique at baseline and every year for 5 years. Statistical analysis was based on Kolmogorov\u2010Smirnov and Wilcoxon signed\u2010rank tests, analysis of covariance, and Spearman's bivariate correlation analysis.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> After 5 years, a reduction in PD of 3.6 \u00b1 0.8 mm (<jats:italic>P<\/jats:italic> = 0.016) and a gain in CAL of 3.0 \u00b1 2.0 mm (<jats:italic>P<\/jats:italic> = 0.01) were registered in the RXT group. There was a slight increase in GR by 0.6 \u00b1 1.4 mm (<jats:italic>P<\/jats:italic> = 0.334). In the PG group, a reduction in PD of 3.5 \u00b1 1.4 mm (<jats:italic>P<\/jats:italic> = 0.01) and a gain in CAL of 3.3 \u00b1 2.1 mm (<jats:italic>P<\/jats:italic> = 0.01) were recorded, whereas GR increased by 0.2 \u00b1 1.7 mm (<jats:italic>P<\/jats:italic> = 0.525). The 1\u2010, 2\u2010, 3\u2010, and 4\u2010year results did not differ significantly from the 5\u2010year results. Radiographically, the defects (the point on the proximal surface of the defective tooth at which the projected alveolar crest intersected the root surface [xCA] to the most coronally located point at the proximal surface of the tooth on the defect side up to which the periodontal ligament space still displayed a uniform width [xBD]) were found to be filled by 47.5% \u00b1 38.3% (<jats:italic>P<\/jats:italic> = 0.001) in the RXT group and by 65.0% \u00b1 50.5% (<jats:italic>P<\/jats:italic> = 0.001) in the PG group. Crestal resorption (the most apical point of the enamel at the proximal surface of the tooth on the defect side [xCEJ] to the xCA) was 19.0% \u00b1 30.2% (<jats:italic>P<\/jats:italic> = 0.374) in the RXT group and 12.3% \u00b1 38.6% (<jats:italic>P<\/jats:italic> = 0.647) in the PG group. The xCEJ to the xBD was significantly more in the PG group (28.4 \u00b1 24.6 versus 7.3 \u00b1 21.8, <jats:italic>P<\/jats:italic> = 0.048). A good standard of oral hygiene and inflammation\u2010free periodontal tissue in the postoperative phase improved the treatment outcome. No dependence of attachment gain was found on the tooth type, number of walls involved in the defects (r = 0.075; <jats:italic>P<\/jats:italic> = 0.319), or intraoperative depth (r = 0.114; <jats:italic>P<\/jats:italic> = 0.307).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Highly significant improvements in the parameters PD and CAL were recorded after 5 years with both regenerative materials. Radiographically, the defects (the xCED to the xBD) were found to be filled significantly more in the bioactive glass group. A good standard of oral hygiene and inflammation\u2010free periodontal tissue in the postoperative phase improved the treatment outcome.<\/jats:p>","DOI":"10.1902\/jop.2006.060029","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T08:53:03Z","timestamp":1160470383000},"page":"1781-1787","source":"Crossref","is-referenced-by-count":52,"title":["Bioabsorbable Membrane and Bioactive Glass in the Treatment of Intrabony Defects in Patients With Generalized Aggressive Periodontitis: Results of a 5\u2010Year Clinical and Radiological 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