{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T20:31:32Z","timestamp":1776889892789,"version":"3.51.2"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A subcategory of chronic neutropenia is chronic benign neutropenia, which is characterized by a prolonged non\u2010cyclic neutropenia as the sole abnormality, with no underlying disease to which the neutropenia can be attributed. Chronic neutropenia is defined as a low absolute neutrophil count for &gt;6 months. In this presentation, periodontitis seems to be the sole manifestation of a juvenile patient with chronic benign neutropenia. A 7\u2010year\u2010old white male presented with periodontitis of the primary dentition and early tooth loss. His medical and dental history was otherwise unremarkable. Suspecting some systemic illness as the underlying cause, the patient was referred for a medical consultation and a series of blood tests.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Blood analyses included a complete blood count (CBC), sequential multiple analyzer 24 (SMA 24), glycated hemoglobin levels, and screening for anti\u2010white blood cell antibodies. Blood levels of calcium, vitamin D, dihydroxyvitamin\u2010D, phosphorus, and alkaline phosphatase were also measured. Liver function tests were performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Following analysis of recent and previous blood test results, a diagnosis of chronic benign neutropenia was assigned. The patient's periodontal condition was treated with scaling and root planing, oral hygiene instruction, and antimicrobial mouthrinses. Three\u2010month recall visits were recommended as a follow\u2010up protocol.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This case represents the importance of diagnosing periodontal disease as a possible indicator of underlying systemic disease. When a patient presents with an unusual, generalized form of periodontal disease, screening for systemic disorders is required, as the oral condition may be the first or only manifestation of a systemic abnormality. This case also illustrates the reason for the change in classification of such a condition to periodontitis as a manifestation of systemic disease. This condition was previously classified as prepubertal periodontitis, a disease diagnosis that focused on the patient's age at the onset of the disease rather than the etiology.<\/jats:p>","DOI":"10.1902\/jop.2006.060076","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T12:54:05Z","timestamp":1162299245000},"page":"1921-1926","source":"Crossref","is-referenced-by-count":23,"title":["Periodontitis as a Manifestation of Chronic Benign Neutropenia"],"prefix":"10.1002","volume":"77","author":[{"given":"Allison","family":"Zaromb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Almas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Blei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.2.114"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1961.32.2.159"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2003.03207.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-61-5-876"},{"key":"e_1_2_7_6_1","first-page":"183","volume-title":"Periodontal Disease in Children and Adolescents","author":"Baer PN","year":"1974"},{"key":"e_1_2_7_7_1","first-page":"45","article-title":"Autoimmune neutropenia","volume":"29","author":"Bux J","year":"1992","journal-title":"Semin Hematol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.5.257"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1980.51.4.206"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.1.51"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027011793.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.6.352"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1983.tb02209.x"},{"key":"e_1_2_7_15_1","first-page":"694","volume-title":"Clinical Periodontology","author":"Glickman I","year":"1958"},{"key":"e_1_2_7_16_1","first-page":"232","article-title":"The clinical relevance of microbiologic testing: A comparative analysis of microbiologic samples secured from the same sites and cultured in two independent laboratories","volume":"21","author":"Mellado JR","year":"2001","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_17_1","first-page":"121","article-title":"The clinical relevance of microbiologic testing. 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