{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:50:32Z","timestamp":1790362232812,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Conventional non\u2010steroidal anti\u2010inflammatory drugs have been widely used in the control of postoperative pain, but sparse information is available on the efficacy of celecoxib, a selective cyclooxygenase\u20102 inhibitor, or dexamethasone, a steroidal anti\u2010inflammatory drug, after periodontal surgeries. The purpose of the present study was to compare the use of celecoxib and dexamethasone in the management of pain after mucoperiosteal flap surgery.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A randomized double\u2010masked cross\u2010over clinical trial was conducted on 20 patients from 27 to 52 years old with generalized moderate to advanced chronic periodontitis. Mucoperiosteal flap surgeries for scaling and root planing were performed under local anesthesia on at least three quadrants, with a 4\u2010week interval between. Each quadrant was randomly assigned to one of the following medication protocols: placebo, 4 mg dexamethasone 1 hour before surgery and 8 hours after the first dose, and 200 mg celecoxib 1 hour before surgery and 12 hours after the first dose. Postoperative pain was accessed during the first 8 hours and on the following 3 days using the visual analog scale (VAS), the 101\u2010point numerical rate scale (NRS\u2010101), and the four\u2010point verbal rating scale (VRS\u20104).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Pain perception was statistically significantly lower in the celecoxib group than in the placebo group during the first 4 hours using VAS (<jats:italic>P<\/jats:italic> = 0.01) and at 1, 2, 3, 4, 6, and 7 hours using NRS\u2010101 (<jats:italic>P<\/jats:italic> = 0.03). The level of pain was lower in the dexamethasone group than in the placebo only at the 3\u2010hour period (<jats:italic>P<\/jats:italic> = 0.001). Statistically significant differences could be found among the groups at 1 hour (<jats:italic>P<\/jats:italic> = 0.015), 3 hours (<jats:italic>P<\/jats:italic> = 0.004), 4 hours (<jats:italic>P<\/jats:italic> = 0.02), and 7 hours (<jats:italic>P<\/jats:italic> = 0.05) using VRS\u20104. There was no statistically significant difference between the celecoxib and dexamethasone groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The findings of this study suggest that the preemptive and postoperative use of celecoxib or dexamethasone were effective in the management of postoperative pain following open\u2010flap debridement.<\/jats:p>","DOI":"10.1902\/jop.2006.060128","type":"journal-article","created":{"date-parts":[[2006,10,31]],"date-time":"2006-10-31T12:54:05Z","timestamp":1162299245000},"page":"1809-1814","source":"Crossref","is-referenced-by-count":45,"title":["The Use of Celecoxib and Dexamethasone for the Prevention and Control of Postoperative Pain After Periodontal Surgery"],"prefix":"10.1002","volume":"77","author":[{"given":"Gibson Luiz","family":"Pilatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Andr\u00e9 dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audilene","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Cavassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudin\u00e9ia W.","family":"Tozetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0303"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.10.597"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1982.0123"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.6.872"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.11.914"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00545.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.2.125"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.4.224"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.3.166"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2004.00558.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-5172.2004.00379.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1321.009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.08.028"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1993.tb07474.x"},{"key":"e_1_2_6_16_1","first-page":"3","volume-title":"Manual for the State\u2010Trait Anxiety Inventory","author":"Spielberger CD","year":"1970"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(86)90228-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00607571"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/009127002401102830"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000073530.81765.6B"},{"key":"e_1_2_6_21_1","first-page":"39","article-title":"Cox\u20102 inhibitors and dental pain control","volume":"71","author":"Jeske AH","year":"1999","journal-title":"J Gt Houst Dent Soc"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0328"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038030-00003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.115"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01060016"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.060128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:35:54Z","timestamp":1760880954000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.060128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1902\/jop.2006.060128"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.060128","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}