{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T18:54:59Z","timestamp":1780772099743,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study was the histologic and ultrastructural evaluation of a biomaterial composed of cortical pig bone in the form of granules.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> After maxillary sinus augmentation using this biomaterial, 10 specimens were retrieved after 5 months in 10 patients using this biomaterial. The specimens were processed to be observed under light microscopy (LM) and transmission electron microscopy (TEM). Histomorphometric measurements were presented by means \u00b1 standard deviations.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> LM showed that most of the particles were surrounded by newly formed bone. In some areas, the osteoid matrix was present; however, mainly compact bone was present at the interface. There was no evidence of an acute inflammatory infiltrate. The newly formed bone was 36% \u00b1 2.8% and marrow spaces were 38% \u00b1 1.6%, whereas residual grafted material was 31% \u00b1 1.6%. Under TEM, all phases of bone formation (osteoid matrix, woven, and lamellar bone) were observed in proximity with the biomaterial particles. The bone\u2010biomaterial interface showed a close contact between the porcine bone particles and the surrounding bone that had mainly features of mature bone with numerous osteocytes. A lamina limitans was sometimes present at this interface.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> According to our knowledge, this is the first study presenting data on TEM of a porcine bone\u2013derived biomaterial used in sinus augmentation procedures in humans. Our findings show that this is a biocompatible biomaterial that can be used for maxillary sinus augmentation procedures without interfering with the normal reparative bone processes.<\/jats:p>","DOI":"10.1902\/jop.2006.060181","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T08:25:32Z","timestamp":1164875132000},"page":"1984-1990","source":"Crossref","is-referenced-by-count":95,"title":["Histologic and Ultrastructural Analysis of Regenerated Bone in Maxillary Sinus Augmentation Using a Porcine Bone\u2013Derived Biomaterial"],"prefix":"10.1002","volume":"77","author":[{"given":"Giovanna","family":"Orsini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Piattelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Piccirilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Caputi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Piattelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"232","article-title":"Maxillary sinus floor elevation for implant placement with demineralized freeze\u2010dried bone and bovine bone (Bio\u2010Oss): A clinical study of 20 patients","volume":"17","author":"Valentini P","year":"1997","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090108.x"},{"key":"e_1_2_8_4_1","first-page":"528","article-title":"Sinus floor elevation using anorganic bovine bone matrix (OsteoGraf\/N) with and without autogenous bone: A clinical, histologic, radiographic, and histomorphometric analysis \u2013 Part 2 of an ongoing prospective study","volume":"18","author":"Froum SJ","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_5_1","first-page":"11","article-title":"Report of the Sinus Consensus Conference of 1996","volume":"13","author":"Jensen OT","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130411.x"},{"key":"e_1_2_8_7_1","first-page":"635","article-title":"A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture","volume":"17","author":"Hallman M","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.328"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.090608.x"},{"key":"e_1_2_8_10_1","first-page":"519","article-title":"Maxillary sinus augmentation: Histologic and histomorphometric analysis","volume":"20","author":"Barone A","year":"2005","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_11_1","first-page":"15","article-title":"Biomaterials and biomechanics of oral and maxillofacial implants: Current status and future developments","volume":"15","author":"Brunski JB","year":"2000","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<426::AID-AR21>3.0.CO;2-Q"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820240704"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19960201)33:2<141::AID-JEMT5>3.0.CO;2-W"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199807)41:1<111::AID-JBM14>3.0.CO;2-Q"},{"key":"e_1_2_8_16_1","first-page":"46","article-title":"Histologic evaluation of the sinus elevation procedure. 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