{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:23:08Z","timestamp":1760919788109,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Myeloid sarcoma is an extramedullary malignancy of myeloblasts. An unusual case of myeloid sarcoma presenting in the gingiva and affected by drug\u2010induced gingival enlargement is presented.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A 63\u2010year\u2010old male taking amlodipine for his hypertension presented with a 3\u2010week gingival enlargement. Although the obvious clinical impression was that of drug\u2010induced gingival enlargement, an incisional biopsy was performed to corroborate chemical enlargement while ruling out diseases such as lymphoma and leukemia.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Microscopic examination of the thickened gingiva revealed surface stratified squamous epithelium having needle\u2010like rete pegs characteristic of drug\u2010induced gingival enlargement. Beneath the surface epithelium, the fibrous tissue was virtually replaced by a dense infiltrate of malignant cells. Immunohistochemical studies were performed with CD117 and myeloperoxidase identifying the malignant cell population as myeloblasts, leading to a diagnosis of myeloid sarcoma.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Myeloid sarcoma and hematopoietic malignancies must be included in a differential diagnosis of gingival enlargement until the definitive diagnosis is reached by histologic\/laboratory examination.<\/jats:p>","DOI":"10.1902\/jop.2006.77.1.119","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T08:36:06Z","timestamp":1136450166000},"page":"119-122","source":"Crossref","is-referenced-by-count":8,"title":["Myeloid Sarcoma Occurring Concurrently With Drug\u2010Induced Gingival Enlargement"],"prefix":"10.1002","volume":"77","author":[{"given":"Angela J.","family":"Yoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Pulse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A.","family":"Lew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Zegarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(02)00024-1"},{"key":"e_1_2_5_3_1","first-page":"818","article-title":"Amlodipine\u2010induced gingival hyperplasia","volume":"51","author":"Routray SN","year":"2003","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.4.211"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2004.tb01681.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00085-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2001.118287"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00024-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(87)90375-6"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80316-0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0266-4356(88)90006-X"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2002.35036"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(90)90065-A"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(87)80039-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(84)90337-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90390-0"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(91)90317-F"},{"key":"e_1_2_5_18_1","first-page":"1","article-title":"Granulocytic sarcoma of the jaw","volume":"30","author":"Takagi M","year":"1983","journal-title":"Bull Tokyo Med Dent Univ"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.10.1514"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.63"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90373-0"},{"key":"e_1_2_5_22_1","first-page":"78","article-title":"Gingival hyperplasia complicating acute myelomonocytic leukemia","volume":"66","author":"Cooper CL","year":"2000","journal-title":"J Can Dent Assoc"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2006.77.1.119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:12:04Z","timestamp":1760865124000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2006.77.1.119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1902\/jop.2006.77.1.119"],"URL":"https:\/\/doi.org\/10.1902\/jop.2006.77.1.119","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}