{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:48:34Z","timestamp":1789847314697,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Bony defects caused by periodontitis are often treated by regenerative therapy using autografts and\/or allografts. Alloplasts, such as hydroxyapatite or ceramics, are also used as osteoconductive materials that serve as a scaffold for new bony ingrowth. The purpose of this study was to determine the effect of hydroxyapatite tricalcium phosphate (HA\u2010TCP) on osseous repair in the rat calvarium.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty\u2010four adult male Harlan Sprague\u2010Dawley rats were assigned to one of four treatment groups: HA\u2010TCP macroporous disk, HA\u2010TCP microporous disk, HA\u2010TCP granules, and demineralized freeze\u2010dried bone (DFDB). The materials were placed into 8\u2010mm calvarial critical\u2010size defects (CSD). Calvariae were harvested at 10 weeks post\u2010surgery and evaluated histomorphometrically.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The DFDB group had significantly (<jats:italic>P<\/jats:italic> &lt;0.05) more new bone formation (47%) than any other group. The HA\u2010TCP macroporous disk group had significantly (<jats:italic>P<\/jats:italic> &lt;0.05) more new bone formation (19.7%) than the HA\u2010TCP microporous disk (8.5%) or HA\u2010TCP granule (6.9%) groups.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The HA\u2010TCP macroporous disk may elicit significant new bone formation due to its rigid space\u2010maintaining scaffold and pore size for vascular ingrowth. It is well tolerated by host tissues and may be a suitable carrier for growth factors.<\/jats:p>","DOI":"10.1902\/jop.2006.77.1.39","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T08:36:06Z","timestamp":1136450166000},"page":"39-45","source":"Crossref","is-referenced-by-count":33,"title":["Effect of a Hydroxyapatite Tricalcium Phosphate Alloplast on Osseous Repair in the Rat Calvarium"],"prefix":"10.1002","volume":"77","author":[{"given":"Kurt B.","family":"Fleckenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Cuenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark E.","family":"Peacock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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