{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:02:34Z","timestamp":1768438954085,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The Women's Interagency HIV Study (WIHS) is the largest, most detailed, controlled longitudinal collection of data to evaluate the influence of human immunodeficiency virus (HIV) disease and its therapies on the periodontium.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This report evaluates periodontal probing depth (PD), attachment loss (AL), and tooth loss from 584 HIV\u2010seropositive and 151 HIV\u2010seronegative women, recorded at 6\u2010month intervals from 1995 to 2002. Using the random split\u2010mouth method, PD and AL were recorded from four sites per tooth: mesial\u2010buccal, buccal, distal\u2010buccal, and lingual. Influence of viral load, CD4 count, race, smoking, drug use, low income, and level of education were evaluated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At baseline, AL was 1.6 versus 1.1 mm (<jats:italic>P<\/jats:italic> = 0.003) and PD was marginally deeper (2.1 versus 2.0 mm; <jats:italic>P<\/jats:italic> = 0.02) in HIV\u2010seropositive versus HIV\u2010seronegative women. Adjusted longitudinal analysis showed that HIV infection did not increase the mean PD (rate ratio [RR], 1.00; 95% confidence interval [CI], 0.96 to 1.04), worst PD (RR, 1.03; 95% CI, 0.98 to 1.09), mean AL (RR, 0.97; 95% CI, 0.96 to 1.02), worst AL (RR, 1.01; 95% CI, 0.94 to 1.07), or tooth loss (RR, 1.02; 95% CI, 1.0 to 1.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> CD4 count and viral load had no consistent effects on PD or AL. Among HIV\u2010infected women, a 10\u2010fold increase in viral load was associated with a marginal increase in tooth loss. The progression of periodontal disease measured by PD and AL did not significantly differ between HIV\u2010infected and HIV\u2010uninfected women. The HIV\u2010seropositive women lost more teeth. Race, smoking, drug use, income, and education level did not influence the results for either group.<\/jats:p>","DOI":"10.1902\/jop.2006.p04039","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T23:25:50Z","timestamp":1146698750000},"page":"773-779","source":"Crossref","is-referenced-by-count":35,"title":["Longitudinal Evaluation of Loss of Attachment in HIV\u2010Infected Women Compared to HIV\u2010Uninfected 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