{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T02:01:37Z","timestamp":1770343297390,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study compares the periodontal clinical profile and the composition of the subgingival microbiota of human immunodeficiency virus (HIV)\u2010seropositive and HIV\u2010seronegative subjects with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 172 subjects were distributed into two HIV\u2010seropositive groups (37 chronic periodontitis [H+CP+] and 35 periodontally healthy [H+CP\u2212] individuals) and two HIV\u2010seronegative groups (49 chronic periodontitis [H\u2212CP+] and 51 periodontally healthy [H\u2212CP\u2212] subjects). Subgingival samples were collected from six sites with the deepest probing depth in the periodontitis groups and six random sites in the groups with periodontal health. All HIV\u2010infected patients had undergone highly active antiretroviral therapy (HAART) for at least 2 years. The presence and levels of 33 bacterial species were detected by DNA probes and the checkerboard method. Kruskal\u2010Wallis and Mann\u2010Whitney tests were used to seek for significant differences among and between groups.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> H\u2212CP+ patients showed significantly more periodontal destruction and inflammation than H+CP+ patients, whereas H+CP\u2212 subjects presented a greater percentage of sites with bleeding than H\u2212CP\u2212 subjects (<jats:italic>P<\/jats:italic> &lt;0.01). Patients who were HIV seronegative showed higher prevalence and levels of most bacterial species than HIV seropositive patients. Periodontal pathogens including <jats:italic>Tannerella forsythensis<\/jats:italic>, <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Prevotella nigrescens<\/jats:italic>, <jats:italic>Eubacterium nodatum<\/jats:italic>, <jats:italic>Fusobacterium nucleatum<\/jats:italic>, and <jats:italic>Selenomonas noxia<\/jats:italic> were more frequently detected in H\u2212CP+ subjects compared to H+CP+ and controls. In contrast, <jats:italic>Enterococcus faecalis<\/jats:italic> and <jats:italic>Acinetobacter baumannii<\/jats:italic> were more commonly found in HIV\u2010infected than in non\u2013HIV\u2010infected subjects (<jats:italic>P<\/jats:italic> &lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Putative periodontal pathogens are more prevalent in the subgingival microbiota of HIV\u2010seronegative patients with chronic periodontitis, whereas species not usually associated with periodontitis are detected in higher frequency in HIV\u2010seropositive subjects under HAART.<\/jats:p>","DOI":"10.1902\/jop.2007.060040","type":"journal-article","created":{"date-parts":[[2007,1,4]],"date-time":"2007-01-04T02:32:33Z","timestamp":1167877953000},"page":"87-96","source":"Crossref","is-referenced-by-count":64,"title":["Clinical and Microbiological Profiles of Human Immunodeficiency Virus (HIV)\u2013Seropositive Brazilians Undergoing Highly Active Antiretroviral Therapy and 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