{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:18:42Z","timestamp":1771474722079,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Genetic polymorphisms of cytokines have been associated with the susceptibility, severity, and clinical outcome of inflammatory diseases, such as periodontitis and chronic arthritis. An important question to address is how interleukin (IL)\u20101 polymorphisms affect the cytokine profiles of patients with such diseases.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study population consisted of Danish white adults, &lt;3\u2010 years of age, who were diagnosed with localized aggressive periodontitis (LAgP, n = 18), generalized aggressive periodontitis (GAgP, n = 27), juvenile idiopathic arthritis (JIA, n = 10), and rheumatoid arthritis (RA, n = 23) and healthy individuals with no systemic or oral diseases (n = 25). Genotypes of IL\u20101A\u2212889, IL\u20101A+4845, IL\u20101B\u2212511, and IL\u20101B+3954 were determined by polymerase chain reaction (PCR)\u2010restriction fragment length polymorphism, and IL\u20101RN variable number tandem repeat (VNTR) was detected by PCR amplification and fragment size analysis. Analysis of variance was used to evaluate the effects of IL\u20101 genotypes on the levels of IL\u20101\u03b1, \u20101\u03b2, \u20101 receptor antagonist, \u20106, and \u201010; tumor necrosis factor\u2010alpha (TNF\u2010\u03b1); and lymphotoxin\u2010\u03b1 in peripheral blood (plasma) and in unstimulated and stimulated whole blood cell cultures from the same blood collection.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The frequencies of IL\u20101 genotypes investigated did not differ significantly between diseased and control individuals. In LAgP patients, allele 2 of IL\u20101RN VNTR was associated with significantly higher levels of IL\u20101\u03b1, \u20106, and \u201010 and TNF\u2010\u03b1, whereas allele 2 of IL\u20101B+39\u20104 was associated with significantly lower levels of the same cytokines. In GAgP patients, a general lack of association was found. In JIA and RA patients, IL\u20101RN VNTR also influenced the cytokine levels.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> IL\u20101 genotypes were associated with cytokine levels in patients with aggressive periodontitis and chronic arthritis. No associations were observed in control individuals.<\/jats:p>","DOI":"10.1902\/jop.2007.060135","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T14:08:16Z","timestamp":1172844496000},"page":"475-492","source":"Crossref","is-referenced-by-count":54,"title":["Polymorphisms Within the IL\u20101 Gene Cluster: Effects on Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures of Patients With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis"],"prefix":"10.1002","volume":"78","author":[{"given":"Anne","family":"Havemose\u2010Poulsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars 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