{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T16:16:50Z","timestamp":1783441010443,"version":"3.54.6"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Bisphosphonates suppress osteoclast activity, and their intravenous use has been reported in hundreds of cases to be associated with osteonecrosis in the jaw. Little is known of the risks associated with long\u2010term use of oral bisphosphonates despite their use for &gt;10 years by an oral mode of delivery for the treatment of osteopenia, osteoporosis, and Paget's disease of bone. The purpose of this report is to review the literature associated with bisphosphonate use that could impact bone healing and to report a case of bone necrosis in a patient on long\u2010term oral bisphosphonates.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A Medline search was carried out to find relevant articles from both medical and dental literature between 1960 and 2006. A patient, who had been taking an oral bisphosphonate for &gt;10 years, developed unexplained clinical signs of bone necrosis after routine dental implant placement. This case was followed, documented, and the treatment of the osteonecrosis described.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A summary of how bisphosphonates may play a role in wound healing is presented. The compromised healing noted in a patient, who was under long\u2010term oral bisphosphonate use, was successfully treated with systemic antibiotics, local microbial mouthrinse, and aggressive defect management (detoxification and mixture of bone graft and tetracycline).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This case suggests that patients under long\u2010term oral bisphosphonate use should be treated with caution. Well\u2010controlled, prospective clinical trials on the effect of oral bisphosphonates on bone are warranted to determine which patients may be at risk for such complications.<\/jats:p>","DOI":"10.1902\/jop.2007.060239","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T14:08:16Z","timestamp":1172844496000},"page":"584-594","source":"Crossref","is-referenced-by-count":102,"title":["Effect of Long\u2010Term Oral Bisphosphonates on Implant Wound Healing: Literature Review and a Case Report"],"prefix":"10.1002","volume":"78","author":[{"given":"Hom\u2010Lay","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie K.","family":"McCauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065192"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/212901a0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr414"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3899.1264"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3899.1262"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-90004-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.56.1.131"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1502"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.61.5.1255"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(02)00079-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81452-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1351\/pac196714010137"},{"key":"e_1_2_7_14_1","first-page":"852","volume-title":"Biochemistry","author":"Moran LA","year":"1994"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(88)90037-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021500"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.11.1668"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002230010047"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0022-3565(24)38786-5","article-title":"Structure\u2010activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen\u2010containing bisphosphonates","volume":"296","author":"Dunford JE","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"e_1_2_7_20_1","first-page":"S66","article-title":"A new mechanism of action for bisphosphonates: Appi dedicated cytotoxicity of N\u2010BPs. 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