{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:35:47Z","timestamp":1791945347935,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Micro\u2010computed tomography (micro\u2010CT) offers significant potential for identifying mineralized structures. However, three\u2010dimensional (3\u2010D) micro\u2010CT of alveolar bone has not been adapted readily for quantification. Moreover, conventional methods are not highly sensitive for analyzing bone loss or bone gain following periodontal disease or reconstructive therapy. The objective of this investigation was to develop a micro\u2010CT methodology for quantifying tooth\u2010supporting alveolar bone in 3\u2010D following experimental preclinical situations of periodontitis or reconstructive therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Experimental in vivo bone loss or regeneration situations were developed to validate the micro\u2010CT imaging techniques. Twenty mature Sprague\u2010Dawley rats were divided into two groups: bone loss (\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    lipopolysaccharide\u2010mediated bone resorption) and regenerative therapy. Micro\u2010CT and software digitized specimens were reconstructed three\u2010dimensionally for linear and volumetric parameter assessment of alveolar bone (linear bone height, bone volume, bone volume fraction, bone mineral content, and bone mineral density). Intra\u2010 and interexaminer reproducibility and reliability were compared for methodology validation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The results demonstrated high examiner reproducibility for linear and volumetric parameters with high intraclass correlation coefficient (ICC) and coefficient of variation (CV). The ICC showed that the methodology was highly reliable and reproducible (ICC &gt;0.99; 9\u2010% confidence interval, 0.937 to 1.000; CV &lt;1.5%), suggesting that 3\u2010D measurements may provide better alveolar bone analysis than conventional 2\u2010D methods.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The developed methods allow for highly accurate and reproducible static measurements of tooth\u2010supporting alveolar bone following preclinical situations of bone destruction or regeneration. Future investigations should focus on using in vivo micro\u2010CT imaging for real\u2010time assessments of alveolar bone changes.\n                  <\/jats:p>","DOI":"10.1902\/jop.2007.060252","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T01:47:00Z","timestamp":1170467220000},"page":"273-281","source":"Crossref","is-referenced-by-count":183,"title":["Three\u2010Dimensional Micro\u2010Computed Tomographic Imaging of Alveolar Bone in Experimental Bone Loss or Repair"],"prefix":"10.1002","volume":"78","author":[{"given":"Chan Ho","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary 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