{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:42:33Z","timestamp":1790854953556,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Pendred syndrome is a rare, inherited, autosomal recessive disorder with an iodine organification defect of thyroxin produced by the thyroid gland. Its clinical features include sensorineural hearing loss, classically congenital and prelingual, and goiter.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This is the first case report of Pendred syndrome in the dental literature with oral findings that include localized extensive attachment loss involving mandibular incisor teeth and idiopathic hypercementosis involving multiple teeth in addition to other oral manifestations, suggesting hypothyroidism\u2010like macroglossia and macrocheilia. Furthermore, serum alkaline phosphatase along with inorganic calcium and phosphate levels were also elevated. Peripheral neutrophil function test suggested a defective function of neutrophils.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Management of the case included augmenting thyroxin supplementation, in consultation with an endocrinologist, and extraction of hopeless mandibular central incisors followed by placement of immediate transitional dentures.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> A comprehensive medical history and systemic and laboratory evaluations should be considered a prerequisite to identify, manage, and report such rare conditions in routine clinical practice.<\/jats:p>","DOI":"10.1902\/jop.2007.060270","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T09:30:34Z","timestamp":1177925434000},"page":"948-954","source":"Crossref","is-referenced-by-count":5,"title":["Localized Attachment Loss in Pendred Syndrome: Incidental?"],"prefix":"10.1002","volume":"78","author":[{"given":"C.G. 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