{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:44Z","timestamp":1788870224376,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE 13102"],"award-info":[{"award-number":["DE 13102"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    We observed that a significant proportion of patients with periodontitis have elevated serum levels of \u03b22\u2010glycoprotein\u2010I\u2013dependent anti\u2010cardiolipin (anti\u2010CL). These prothrombotic autoantibodies, commonly found to be elevated in patients with systemic lupus erythematosus and the antiphospholipid syndrome, are associated with adverse pregnancy outcomes, such as fetal involution, prematurity, and low birth weight, and with cardiovascular sequelae, such as atherosclerosis, stroke, and myocardial infarction. Anti\u2010CL is known to promote vascular inflammation and thrombosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We measured serum levels of markers of vascular inflammation, including soluble intercellular adhesion molecule (sICAM)\u20101, soluble vascular cell adhesion molecule (sVCAM)\u20101, and sE\u2010selectin, in 190 subjects with generalized aggressive or chronic periodontitis and in 90 periodontally healthy subjects.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    sVCAM\u20101 and sE\u2010selectin levels were significantly higher in patients with elevated anti\u2010CL (&gt;1\u2010 U\/ml). This relationship also was observed in the never\u2010smoker subset of subjects, even after correction for demographic and periodontal variables. Within the diagnostic categories, sICAM\u20101, sVCAM\u20101, and sE\u2010selectin were significantly higher in generalized aggressive periodontitis patients who had elevated anti\u2010CL compared to those with normal anti\u2010CL. Statistical correction for demographic and periodontal variables indicated that elevated anti\u2010CL remained significantly associated with increased sVCAM\u20101 and sE\u2010selectin in generalized aggressive periodontitis patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Systemic markers of vascular inflammation in patients with aggressive periodontitis are associated with elevated levels of anti\u2010CL. We hypothesize that a subset of periodontitis patients with elevated antiphospholipid antibodies could represent a subgroup at increased risk for obstetrical and cardiovascular sequelae.\n                  <\/jats:p>","DOI":"10.1902\/jop.2007.060305","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T14:08:16Z","timestamp":1172844496000},"page":"459-466","source":"Crossref","is-referenced-by-count":30,"title":["Anti\u2010Cardiolipin and Increased Serum Adhesion Molecule Levels in Patients With Aggressive Periodontitis"],"prefix":"10.1002","volume":"78","author":[{"given":"Harvey A.","family":"Schenkein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al M.","family":"Best","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol 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