{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:58:11Z","timestamp":1788044291742,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Regenerative periodontal therapy with a combination of platelet\u2010rich plasma (PRP) + an anorganic bovine bone mineral (ABBM) + guided tissue regeneration (GTR) has been shown to result in significantly higher probing depth reductions and clinical attachment level gains compared to treatment with open flap debridement (OFD) alone, ABBM alone, or GTR alone. However, there are no data evaluating to what extent the use of PRP may additionally enhance the clinical outcome of the therapy compared to treatment with ABBM + GTR. This study aimed to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with ABBM and GTR by means of a non\u2010resorbable expanded polytetrafluoroethylene (ePTFE) membrane.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Twenty\u2010four patients with advanced chronic periodontal disease and displaying one intrabony defect were randomly treated with a combination of either PRP + ABBM + GTR or ABBM + GTR. The following clinical parameters were evaluated at baseline and at 1 year after treatment: plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR), and clinical attachment level (CAL). The primary outcome variable was CAL.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    No differences in any of the studied parameters were observed at baseline between the two groups. Healing was uneventful in all patients. At 1 year after therapy, the sites treated with PRP + ABBM + GTR showed a reduction in mean PD from 8.6 \u00b1 1.7 mm to 3.1 \u00b1 1.3 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) and a change in mean CAL from 10.3 \u00b1 1.4 mm to 5.7 \u00b1 1.6 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). In the group treated with ABBM + GTR, mean PD was reduced from 8.8 \u00b1 1.7 mm to 3.1 \u00b1 1.0 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001), and the mean CAL changed from 10.4 \u00b1 2.6 mm to 5.9 \u00b1 1.8 mm (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). In both groups, all sites gained \u22653 mm of CAL. CAL gains \u22654 mm were measured in 83% (i.e., in 10 of 12 defects) of the cases treated with PRP + ABBM + GTR and in 92% (i.e., in 11 of 12 defects) treated with ABBM + GTR. No statistically significant differences in any of the studied parameters were observed between the two groups at 1\u2010year reevaluation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Within its limits, the present study has shown that, at 1 year after regenerative therapy in periodontal intrabony defects, optimal clinical results were obtained with ABBM + GTR with a non\u2010resorbable barrier, with or without the addition of PRP.\n                  <\/jats:p>","DOI":"10.1902\/jop.2007.060349","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T08:27:43Z","timestamp":1180600063000},"page":"983-990","source":"Crossref","is-referenced-by-count":58,"title":["Effect of Platelet\u2010Rich Plasma on the Healing of Intrabony Defects Treated With an Anorganic Bovine Bone Mineral and Expanded Polytetrafluoroethylene Membranes"],"prefix":"10.1002","volume":"78","author":[{"given":"Ferenc","family":"D\u00f6ri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Husz\u00e1r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris","family":"Nikolidakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Gera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"650","volume-title":"Clinical Periodontology and Implant Dentistry","author":"Karring T","year":"2003"},{"key":"e_1_2_7_3_1","first-page":"321","article-title":"Clinical, radiographic, and histologic evaluation of human periodontal defects treated with Bio\u2010Oss and Bio\u2010Gide","volume":"18","author":"Camelo M","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_4_1","first-page":"19","article-title":"Human histologic evaluation of a bovine\u2010derived xenograft in the treatment of periodontal osseous defects","volume":"20","author":"Mellonig J","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_5_1","first-page":"47","article-title":"Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative combined with a bovine\u2010derived xenograft","volume":"23","author":"Sculean A","year":"2003","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-004-0254-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012889.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.2.158"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10192.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00562.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00208.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.12.1158"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.7.458"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01679.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00403.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.5.429"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1186"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2205"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_7_21_1","first-page":"664","article-title":"Platelet\u2010rich plasma: A promising innovation in dentistry","volume":"69","author":"Tozum TF","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_7_22_1","first-page":"93","article-title":"Is platelet\u2010rich plasma the perfect enhancement factor? 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