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Inflammation is mediated by proinflammatory cytokines; recently, a novel subset of T\u2010helper (Th) cells was identified that plays a crucial role in inflammation and autoimmune disease. This population secretes several proinflammatory cytokines, including the novel cytokine interleukin (IL)\u201017, and, hence, has been termed \u201cTh17.\u201d Inflammatory cytokines are implicated in the progression of localized chronic infections, such as PD, and in serious systemic pathologies, such as diabetes, chronic obstructive pulmonary disease, and cardiovascular disease. IL\u201017 mediates inflammation through a receptor (IL\u201017R) composed of two subunits, IL\u201017RA and IL\u201017RC. Drugs that antagonize inflammatory cytokines are used therapeutically to downregulate immune\u2010mediated pathology in conditions such as RA, although not all patients respond well to this approach. Therefore, identification of potential novel therapeutic targets, such as the IL\u201017 signaling complex, may be clinically relevant for mitigating inflammatory pathology. However, the manner in which such a therapeutic may influence the onset and progression of PD is poorly understood. Therapeutics that antagonize inflammatory cytokines ameliorate inflammation and bone loss and may have broader implications for individuals with systemic diseases in which inflammation and autoimmunity predominate.<\/jats:p>","DOI":"10.1902\/jop.2007.060392","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T08:27:43Z","timestamp":1180600063000},"page":"1083-1093","source":"Crossref","is-referenced-by-count":118,"title":["Interleukin\u201017: A New Paradigm in Inflammation, Autoimmunity, and Therapy"],"prefix":"10.1002","volume":"78","author":[{"given":"Jill M.","family":"Kramer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Gaffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.11-S.2075"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.06.002"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1807"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1478"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1444"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R200003200"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.1.1"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.018"},{"key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.4049\/jimmunol.136.7.2348","article-title":"Two types of murine helper T cell clones. 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