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Melatonin has powerful antioxidant effects, functions in an immunomodulatory role, may protect against certain cancers, delays some age\u2010related processes, stimulates the synthesis of type I collagen fibers, and promotes bone formation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> An extensive review was made (e.g., using PubMed, Science Direct, and Web of Knowledge) of the literature.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Melatonin, which is released into the saliva, may have important implications for dental disorders, especially in periodontal disease. Diseases of the periodontium are known to be aggravated by free radicals and by alterations in the immune response to microorganisms that are present in plaque. In response to periodontal inflammation, the blood and salivary levels of melatonin may increase.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Melatonin may play a role in protecting the oral cavity from tissue damage that is due to oxidative stress, and it may contribute to the regeneration of alveolar bone through the stimulation of type I collagen fiber production and the modulation of osteoblastic and osteoclastic activity.<\/jats:p>","DOI":"10.1902\/jop.2007.060396","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T08:27:43Z","timestamp":1180600063000},"page":"1094-1102","source":"Crossref","is-referenced-by-count":105,"title":["Melatonin: Potential Functions in the Oral 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