{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:43:41Z","timestamp":1760921021809,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Nerve sheath myxoma (NSM) is an extremely rare benign neoplasm in the oral cavity. This paper describes the first case, to our knowledge, of NSM in the gingival mucosa of an 84\u2010year\u2010old female patient.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Intraoral examination revealed a painless and well\u2010defined nodule in the lingual gingival mucosa of the right mandibular lateral incisor, which measured \u223c1.0 cm in diameter. The lesion was fully excised under local anesthesia, without intercurrences. Hematoxylin and eosin staining was performed in 5\u2010\u03bcm sections for histopathologic analysis. Immunohistochemical reactions against vimentin and S\u2010100 protein were carried out in 3\u2010\u03bcm histologic sections in accordance with manufacturers' instructions.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The patient's medical history and an extraoral exam did not reveal other abnormalities. The patient wore a removable partial denture in the affected area. A trauma\u2010induced gingival hyperplasia was the main diagnostic hypothesis. Microscopically, the lesion was composed of an abundant myxoid matrix and stellated and spindle\u2010shaped cells arranged in lobules separated by fine fibrous septa. The cells presented strong positivity for vimentin and S\u2010100 protein. According to the histopathologic and immunohistochemical features, the diagnosis of NSM was established. After 9 months of treatment, no signs or symptoms of recurrences have been observed.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Although NSM is an extremely rare oral tumor, it should be considered in the clinical differential diagnosis of gingival nodules.<\/jats:p>","DOI":"10.1902\/jop.2007.060425","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T09:22:59Z","timestamp":1185960179000},"page":"1639-1643","source":"Crossref","is-referenced-by-count":9,"title":["Nerve Sheath Myxoma of the Gingiva: Report of a Rare Case and Review of the Literature"],"prefix":"10.1002","volume":"78","author":[{"given":"Jos\u00e9 D.","family":"Prado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo G.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara T.C.","family":"Silva\u2010Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia F.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando A.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyel E.C.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00835.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.12.016"},{"key":"e_1_2_5_4_1","first-page":"60","volume-title":"Atlas of Tumor Pathology","author":"Harkin JC","year":"1969"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/74.6.759"},{"key":"e_1_2_5_6_1","first-page":"135","article-title":"Peripheral ossifying fibroma. 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