{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:24:01Z","timestamp":1777487041115,"version":"3.51.4"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The treatment of aggressive periodontitis has always presented a challenge for clinicians, but there are no established protocols and guidelines for the efficient control of the disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Ten patients with a clinical diagnosis of aggressive periodontitis were treated in a split\u2010mouth design study to either photodynamic therapy (PDT) using a laser source with a wavelength of 690 nm associated with a phenothiazine photosensitizer or scaling and root planing (SRP) with hand instruments. Clinical assessment of plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR), and relative clinical attachment level (RCAL) were made at baseline and 3 months after treatment with an automated periodontal probe.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Initially, the PI was 1.0 \u00b1 0.5 in both groups. At the 3\u2010month evaluation, the plaque scores were reduced and remained low throughout the study. A significant reduction of GI and BOP occurred in both groups after 3 months (<jats:italic>P<\/jats:italic> &lt;0.05). The mean PD decreased in the PDT group from 4.92 \u00b1 1.61 mm at baseline to 3.49 \u00b1 0.98 mm after 3 months (<jats:italic>P<\/jats:italic> &lt;0.05) and in SRP group from 4.92 \u00b1 1.14 mm at baseline to 3.98 \u00b1 1.76 mm after 3 months (<jats:italic>P<\/jats:italic> &lt;0.05). The mean RCAL decreased in the PDT group from 9.93 \u00b1 2.10 mm at baseline to 8.74 \u00b1 2.12 mm after 3 months (<jats:italic>P<\/jats:italic> &lt;0.05), and in the SRP group, from 10.53 \u00b1 2.30 mm at baseline to 9.01 \u00b1 3.05 mm after 3 months.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> PDT and SRP showed similar clinical results in the non\u2010surgical treatment of aggressive periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2007.060494","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T08:27:43Z","timestamp":1180600063000},"page":"965-973","source":"Crossref","is-referenced-by-count":159,"title":["Antimicrobial Photodynamic Therapy in the Non\u2010Surgical Treatment of Aggressive Periodontitis: A Preliminary Randomized Controlled Clinical Study"],"prefix":"10.1002","volume":"78","author":[{"given":"Rafael R.","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humberto O.","family":"Schwartz\u2010Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Arthur B.","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"M\u00e1rio","family":"Taba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00605.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1984.tb00819.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(84)90043-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb02338.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.11.1143"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0087"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.4.727-752.2001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.275"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.00004.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(03)00039-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-135-5-1291"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/26.1.1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028007597.x"},{"key":"e_1_2_7_15_1","first-page":"2","article-title":"Action of the alcaloids in the vegetable and animal kingdoms (in Italian)","volume":"9","author":"Marcacci A","year":"1888","journal-title":"Arch Ital Biol"},{"key":"e_1_2_7_16_1","first-page":"524","article-title":"The effect of fluorescent agents on infusoria (in German)","volume":"39","author":"Raab O","year":"1900","journal-title":"Z Biol"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90080-L"},{"key":"e_1_2_7_18_1","first-page":"335","article-title":"Bactericidal effects induced by laser irradiation and haematoporphyrin against Gram\u2010positive and Gram\u2010negative microorganisms","volume":"12","author":"Martinetto P","year":"1986","journal-title":"Drugs Exp Clin Res"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1993.tb02780.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/79.9.839"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01570963"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)0720676TEOPAO2.0.CO2"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.932-940.2003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.7.1100"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.8.1237"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00626.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.300105.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1994.tb00020.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345840630031101"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.2.118"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb00877.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb02248.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02459.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb02249.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280103.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2004.03675.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1980.tb00268.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00765.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb00029.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.6.574"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1993.tb01070.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2595"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.10.1343"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01570963"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.413"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10208"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.2.93"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.3.361"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02024.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01309.x"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.772"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012897.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.6.325"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.6.562"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02372.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1999.tb02521.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/16.Supplement_4.S310"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1998.tb09694.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1977.tb07360.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2007.060494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:38:36Z","timestamp":1760881116000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2007.060494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1902\/jop.2007.060494"],"URL":"https:\/\/doi.org\/10.1902\/jop.2007.060494","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}