{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:21:53Z","timestamp":1760919713055,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Inflammation contributes to the pathogenesis of diabetes. A reciprocal relationship exists between diabetes and chronic periodontitis. This report describes the effects of an acute focal dental inflammation and subsequent endodontic treatment on the required insulin dosage of a 70\u2010year\u2010old man who had moderately controlled diabetes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Following an exacerbation of a combined endodontic\u2010periodontic (endo\u2010perio) lesion of tooth #3, the patient noticed a sudden increase in his insulin demand. After 3 weeks, the required dosage was \u223c100% greater. In association with hyperglycemic incidents, he reported a prickling sensation in this tooth. The radiograph showed circular bone loss around the tooth.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Just 1 day after the root\u2010canal preparation, the insulin need decreased to \u223c50% of that required prior to treatment. Subsequently, an incision and systemic antibiotics were necessary because of the formation of a periodontal abscess. The insulin demand remained low despite this complication. Forty days after endodontic treatment, the insulin dosage was at a level comparable to that taken 4 weeks before the root\u2010canal preparation.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This clinical case revealed a highly relevant correlation between insulin resistance and a local dental inflammation. To avoid an increase in insulin resistance, it seems important to attend to radically non\u2010vital teeth as well as any other dental inflammation in diabetic patients.<\/jats:p>","DOI":"10.1902\/jop.2007.070033","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T08:34:09Z","timestamp":1196411649000},"page":"2380-2384","source":"Crossref","is-referenced-by-count":15,"title":["Sudden Improvement of Insulin Sensitivity Related to an Endodontic Treatment"],"prefix":"10.1002","volume":"78","author":[{"given":"A.","family":"Schulze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sch\u00f6nauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Busse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","article-title":"Periodontitis: From local infection to systemic diseases","volume":"18","author":"D'Aiuto F","year":"2005","journal-title":"Int J Immunopathol Pharmacol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1004583"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00658.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0404"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050061"},{"key":"e_1_2_6_7_1","first-page":"7","article-title":"The effect of periodontal therapy on TNF\u2010alpha, IL\u20106 and metabolic control in type 2 diabetics","volume":"80","author":"Talbert J","year":"2006","journal-title":"J Dent Hyg"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2005.00996.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050184"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050459"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200207000-00005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25102"},{"key":"e_1_2_6_13_1","unstructured":"EngebretsonSP BhattacharyyaJ Hey\u2010HadaviJ et al. Plasma endotoxin in periodontitis patients: A pilot study. Available at:http:\/\/iadr.confex.com\/iadr\/2002SanDiego\/techprogram\/abstract_21669.htm. 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