{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:33:13Z","timestamp":1792708393478,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The effects of periodontal disease on the oral gingival epithelium (OGE) have not been documented fully because they may not be as dramatic as those seen on the junctional epithelium. The aim of this study was to estimate the changes occurring in the OGE with respect to its proliferation and E\u2010cadherin and cytokeratin 19 (K19) expression during pocket formation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingival samples were collected from 17 periodontally healthy subjects and 18 subjects with chronic periodontitis. K19 and E\u2010cadherin levels were analyzed immunohistochemically. The net proliferative rate was calculated as the difference between the proliferative rate and the apoptotic rate as determined by immunohistochemical analysis of Ki\u201067 and p53, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a significant increase in the net proliferative rate of the OGE during pocket formation (periodontitis group, 220.90 \u00b1 46.85; healthy group, 107.60 \u00b1 25.86; <jats:italic>P<\/jats:italic> &lt;0.001). There was a significant reduction in E\u2010cadherin expression (periodontitis group, 0.837 \u00b1 0.428; healthy group, 1.846 \u00b1 0.555) and a significant increase in K19 expression during pocket formation (periodontitis group, 1.45 \u00b1 0.686; healthy group, 0.533 \u00b1 0.410).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> OGE appears to undergo significant changes in proliferation and differentiation during pocket formation that do not seem to be restricted to proteolytic destruction by the invading microorganisms.<\/jats:p>","DOI":"10.1902\/jop.2007.070070","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T06:55:40Z","timestamp":1193813740000},"page":"2197-2202","source":"Crossref","is-referenced-by-count":32,"title":["Differential Expression of E\u2010Cadherin and Cytokeratin 19 and Net Proliferative Rate of Gingival Keratinocytes in Oral Epithelium in Periodontal Health and Disease"],"prefix":"10.1002","volume":"78","author":[{"given":"S.","family":"Nagarakanti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ramya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Babu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.V.","family":"Arun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabitha","family":"Sudarsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.03007.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2002.66.4.tb03536.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/08959374990130011601"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.11.1070"},{"key":"e_1_2_7_6_1","first-page":"235","article-title":"Pathogenesis 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