{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:24:20Z","timestamp":1760919860013,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Infection control is an important requirement during the early stages of periodontal healing. This study was performed to assess the preconditioning effect of EDTA gel on chlorhexidine (CHX) substantivity to periodontally involved root surfaces.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eighty patients with severe chronic periodontitis were enrolled in this study. Following cause\u2010related therapy, patients were divided randomly into four groups. Each group consisted of 20 subjects with one tooth that was diagnosed as hopeless and designated for extraction. In group 1 (G1), selected periodontal pockets were filled with a placebo gel in a silica base for 2 minutes. Exposed roots in group 2 (G2) were etched for 2 minutes with a neutral EDTA conditioning agent, followed by pocket fill with the placebo gel. Pockets in group 3 (G3) were filled with 0.12% CHX digluconate gel in a silica base. Exposed roots in group 4 (G4) were etched for 2 minutes with a neutral EDTA conditioning agent, followed by pocket fill with the CHX gel. Four teeth from each group were extracted immediately and at 3, 12, 24, and 48 hours for SEM evaluation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> G1 and G2 specimens showed no evidence of silica adherent to any of the examined root surfaces. At 3 hours following CHX gel application, G3 specimens showed marked reduction in CHX\u2010coated silica. At 24 and 48 hours following EDTA and CHX gel application, G4 specimens demonstrated adherent CHX\u2010coated silica particles despite the reclogging of the tubule orifices.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> EDTA and CHX gel root conditioning is a valuable regimen that improves CHX substantivity to periodontally involved root surfaces.<\/jats:p>","DOI":"10.1902\/jop.2007.070124","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T07:46:35Z","timestamp":1188546395000},"page":"1759-1766","source":"Crossref","is-referenced-by-count":14,"title":["Effects of EDTA Gel Preconditioning of Periodontally Affected Human Root Surfaces on Chlorhexidine Substantivity \u2013 An SEM Study"],"prefix":"10.1002","volume":"78","author":[{"given":"Ahmed Y.","family":"Gamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Mailhot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.9.672"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1982.tb02066.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02463.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1987.tb00984.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00178.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345930720020501"},{"key":"e_1_2_8_8_1","first-page":"11","article-title":"The effects of EDTA gel conditioning exposure time on periodontitis\u2010affected human root surfaces: Surface topography and PDL cell adhesion","volume":"5","author":"Gamal AY","year":"2003","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1964.tb07384.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2002.01003.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-2399(98)80049-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1973.tb02167.x"},{"key":"e_1_2_8_13_1","first-page":"1209","article-title":"Retention of chlorhexidine in the human oral cavity after mouth rinses","volume":"19","author":"Bonesvoll PP","year":"1974","journal-title":"Arch Oral Biol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb00051.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1981.tb02040.x"},{"key":"e_1_2_8_16_1","first-page":"7","article-title":"The effect of chlorhexidine on the microflora of the oral cavity","volume":"12","author":"Schiott CR","year":"1973","journal-title":"J Periodontal Res Suppl"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb01135.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb02534.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.1.47"},{"key":"e_1_2_8_20_1","first-page":"41","article-title":"Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis","volume":"29","author":"Awartani FA","year":"1998","journal-title":"Quintessence Int"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1999.eos107601.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027012910.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00620.x"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.4.411"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00742.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280104.x"},{"key":"e_1_2_8_27_1","article-title":"Osteoconductive effects of Vinyl Styrene Microbeads in rat calvarial defects","author":"Marzouk KM","year":"2006","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_2_8_28_1","first-page":"1625","article-title":"Pharmacokinetic principles controlling efficacy of oral therapy","volume":"68","author":"Goodson J","year":"1989","journal-title":"J Dent Res"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00225.x"},{"key":"e_1_2_8_30_1","first-page":"560","article-title":"A clinical study of root surface conditioning with an EDTA gel. 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