{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:24:30Z","timestamp":1760919870157,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["RO1 DE12215"],"award-info":[{"award-number":["RO1 DE12215"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Information on the efficacy of chlorhexidine (CHX) rinsing on the subgingival microbiota is limited. This study tested if intermittent CHX rinsing over 5 years had an impact on the subgingival microbiota.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Subgingival plaque samples were analyzed by the checkerboard DNA\u2010DNA hybridization method in a double\u2010blind randomized CHX rinse study.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 210 subjects were included. The mean age of the subjects was 71.7 (\u00b1 4.1) years, and 56.2% were women. Evidence of alveolar bone loss was found in 39% of subjects. Bacterial loads were not correlated significantly with probing depth. At year 5, subjects in the CHX rinse group with no evidence of bone loss presented with lower total bacterial counts than control subjects with no bone loss. The levels of the following bacteria were significantly lower in the CHX group: <jats:italic>Lactobacillus acidophilus<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05), <jats:italic>Eikenella corrodens<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05), <jats:italic>Fusobacterium nucleatum<\/jats:italic> sp. <jats:italic>nucleatum<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.01), <jats:italic>Treponema denticola<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05), <jats:italic>Leptotrichia buccalis<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05), and <jats:italic>Eubacterium saburreum<\/jats:italic> (<jats:italic>P<\/jats:italic> &lt;0.05). No differences in bacterial loads were found between CHX and control rinse subjects with alveolar bone loss.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Older subjects with or without periodontitis carry a large variety of bacteria associated with periodontitis. Intermittent rinsing with CHX may provide a preventive benefit in reducing levels of bacteria but only in subjects without alveolar bone loss.<\/jats:p>","DOI":"10.1902\/jop.2007.070138","type":"journal-article","created":{"date-parts":[[2007,8,31]],"date-time":"2007-08-31T07:46:35Z","timestamp":1188546395000},"page":"1751-1758","source":"Crossref","is-referenced-by-count":18,"title":["The Impact of a Low\u2010Frequency Chlorhexidine Rinsing Schedule on the Subgingival Microbiota (the TEETH clinical trial)"],"prefix":"10.1002","volume":"78","author":[{"given":"G. Rutger","family":"Persson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Yeates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigmor E.","family":"Persson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regula","family":"Hirschi\u2010Imfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Weibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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