{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:48:54Z","timestamp":1777254534768,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Additional clinical benefits have been reported with the use of locally delivered antimicrobials in the treatment of smokers; however, long\u2010term changes in the subgingival microbiota following the use of these drugs in smokers have not been documented. The aim of this study was to evaluate long\u2010term microbiologic changes following locally delivered doxycycline in the treatment of smokers.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixteen smokers with chronic periodontitis presenting a minimum of four pockets (probing depth \u22655 mm) were selected. Patients were assigned randomly to receive scaling and root planing (SRP) or SRP and local doxycycline (SRP\u2010D). Patients were treated at baseline and 12 months. Subgingival plaque samples were collected at baseline; 3, 6, and 12 months; and 45 and 90 days following retreatment. Polymerase chain reaction and DNA\u2013DNA hybridization analyses were performed to detect the presence of selected periodontal pathogens.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The reduction in the number of sites positive for <jats:italic>Porphyromonas gingivalis<\/jats:italic> and <jats:italic>Tannerella forsythia<\/jats:italic> (previously <jats:italic>T. forsythensis<\/jats:italic>) was statistically significant for SRP\u2010D at 3 months (68% and 41.3%, respectively) and for SRP at 6 months (75% and 52%, respectively) following treatment. The SRP group showed a greater frequency of <jats:italic>P. gingivalis<\/jats:italic> than the SRP\u2010D group at 3 months (58% and 25%, respectively). There also was a greater reduction in the frequency of <jats:italic>P. gingivalis<\/jats:italic> at 3 months following retreatment with SRP\u2010D compared to SRP (47% and 8%, respectively).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In smokers, adjunctive local doxycycline resulted in a greater reduction in the frequency of <jats:italic>P. gingivalis<\/jats:italic> following initial and supportive therapy compared to conventional treatment.<\/jats:p>","DOI":"10.1902\/jop.2007.070189","type":"journal-article","created":{"date-parts":[[2007,10,31]],"date-time":"2007-10-31T06:55:40Z","timestamp":1193813740000},"page":"2143-2149","source":"Crossref","is-referenced-by-count":15,"title":["Microbiologic Changes Following Administration of Locally Delivered Doxycycline in Smokers: A 15\u2010Month Follow\u2010Up"],"prefix":"10.1002","volume":"78","author":[{"given":"Luciana 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