{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:25:26Z","timestamp":1770042326058,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The pathogenesis of epithelial thickening in gingival overgrowth remains obscure. Apoptosis plays an important role in maintaining tissue hemostasis. The aim of the present study was to investigate apoptosis via immunohistochemical analyses in cyclosporin A\u2013induced gingival overgrowth tissue samples to determine whether these processes play a role in the pathogenesis of gingival overgrowth.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Gingival biopsies (one per person) were harvested from 22 renal transplant recipients (eight men and 14 women; mean age, 36.4 \u00b1 13.3 years) who had been diagnosed with cyclosporin A\u2013induced gingival enlargement and from 12 systemically healthy persons (seven men and five women; mean age, 27.0 \u00b1 16.0 years) with plaque\u2010induced gingivitis. Distributions of caspase\u20103 and apoptosis were determined immunologically.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Significant differences were found with regard to caspase\u20103 levels and the extent of apoptosis between the cyclosporin A group and the control group. Plaque index, gingival index, and probing depths were significantly lower in the control group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The extent of keratinocyte apoptosis and decreased levels of caspase\u20103 may be an important factor affecting the gingiva of kidney transplant recipients with cyclosporin A\u2010induced gingival overgrowth.<\/jats:p>","DOI":"10.1902\/jop.2007.070226","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T08:34:09Z","timestamp":1196411649000},"page":"2364-2368","source":"Crossref","is-referenced-by-count":14,"title":["Apoptosis and Expression of Caspase\u20103 in Cyclosporin\u2010Induced Gingival Overgrowth"],"prefix":"10.1002","volume":"78","author":[{"given":"Sule","family":"Bulut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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