{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:17:37Z","timestamp":1784967457051,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> This study compared clinical and radiographic findings for the treatment of Class II furcation defects in human mandibular molars using anorganic bovine\u2010derived hydroxyapatite matrix (ABM)\/cell\u2010binding peptide (P\u201015) or open flap debridement (OFD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twelve subjects showing two comparable Class II furcation defects in their mandibular molars were enrolled. The defects in each subject were assigned randomly to the test (ABM\/P\u201015) or the control (OFD) group. Clinical measurements and standardized radiographs were taken at baseline and 6 to 7 months after surgery.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There were no statistically significant differences between the test and control groups for any clinical or radiographic parameter (<jats:italic>P<\/jats:italic> &gt;0.05). On comparing the baseline and final measurements, the gain in horizontal clinical attachment level and reduction in gingival recession were significant only in the test group (<jats:italic>P<\/jats:italic> \u22640.02), whereas the gain in the vertical clinical attachment level was significant in both groups (<jats:italic>P<\/jats:italic> \u22640.04). In the test group, four of 12 sites showed complete closure, and five showed partial closure; in the control group, three defects showed complete closure, and four showed partial closure (<jats:italic>P<\/jats:italic> = 0.42). Subtraction radiography revealed similar gains in bone height and increases in mean bone density with both treatments (<jats:italic>P<\/jats:italic> &gt;0.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> ABM\/P\u201015 yielded favorable results in the treatment of Class II furcation defects over a 6\u2010month evaluation period; however, there was no difference compared to OFD. Further studies using a larger sample size are needed to confirm the present findings.<\/jats:p>","DOI":"10.1902\/jop.2007.070234","type":"journal-article","created":{"date-parts":[[2007,11,30]],"date-time":"2007-11-30T08:34:09Z","timestamp":1196411649000},"page":"2277-2283","source":"Crossref","is-referenced-by-count":14,"title":["Use of Anorganic Bovine\u2010Derived Hydroxyapatite Matrix\/Cell\u2010Binding Peptide (P\u201015) in the Treatment of Class II Furcation Defects: A Clinical and Radiographic Study in Humans"],"prefix":"10.1002","volume":"78","author":[{"given":"Ana L.","family":"Eto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Jeffcoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ney S.","family":"de 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