{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:35:30Z","timestamp":1773246930584,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Interleukin (IL)\u20101 is closely related to the initiation and progression of periodontal disease. IL\u20101 levels in the gingival crevicular fluid (GCF) of subjects with periodontitis are higher than those in periodontally healthy controls, and the levels of IL\u20101 correlate with disease severity. However, soluble IL\u20101 receptor type II (sIL\u20101RII), which acts as a decoy receptor for IL\u20101s, has not been investigated in detail in periodontal disease. The purpose of this study was to measure sIL\u20101RII levels in the GCF of subjects with chronic or aggressive periodontitis; the correlation between the sIL\u20101RII levels in GCF and clinical parameters also was examined.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> IL\u20101\u03b2 and sIL\u20101RII were measured in 64 GCF samples collected from 47 subjects with chronic periodontitis (CP) and 17 subjects with aggressive periodontitis (AgP). The clinical characteristics of each site were recorded at the time of GCF sampling. IL\u20101\u03b2 and sIL\u20101RII were measured by specific non\u2013cross\u2010reactive enzyme\u2010linked immunosorbent assay.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The disease severity was comparable in CP and AgP. IL\u20101\u03b2 was detected in 98% of CP GCF samples and 88% of AgP GCF samples. sIL\u20101RII was detected in 55% of CP GCF samples and 35% of AgP GCF samples. However, the concentrations of IL\u2010\u03b2 and sIL\u20101RII detected in GCF from subjects with CP or AgP were similar.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> sIL\u20101RII was detected more often in CP GCF than in AgP GCF, and there was no correlation between GCF sIL\u20101RII concentration and clinical parameters.<\/jats:p>","DOI":"10.1902\/jop.2008.070111","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T09:21:35Z","timestamp":1204536095000},"page":"495-500","source":"Crossref","is-referenced-by-count":10,"title":["Soluble Interleukin\u20101 Receptor Type II Levels in Gingival Crevicular Fluid in Aggressive and Chronic Periodontitis"],"prefix":"10.1002","volume":"79","author":[{"given":"M.","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Suga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kamei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.8.1045"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb00896.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.8.835"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1997.tb00568.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1998.18.491"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.1.18-23.1991"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01639.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.5.1893-1898.1995"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1995.tb00121.x"},{"key":"e_1_2_7_11_1","first-page":"229","article-title":"Membrane\u2010associated interleukin\u20101 on macrophages stimulated with Actinobacillus actinomycetemcomitans lipopolysaccharide induces osteoclastic bone resorption in vivo","volume":"81","author":"Nishihara T","year":"1995","journal-title":"Cytobios"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6155"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830189809043005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta8180"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1959.30.1.7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290108.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.12.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-5712(96)00084-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70185-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199806)41:6<1083::AID-ART15>3.0.CO;2-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03335-6"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.5999"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)99886-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8332913"},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.4049\/jimmunol.159.12.6226","article-title":"IFN\u2010\u03b3 and IL\u201010 inhibit induction of IL\u20101 receptor type I and type II gene expression by IL\u20104 and IL\u201013 in human monocytes","volume":"159","author":"Dickensheets HL","year":"1997","journal-title":"J Immunol"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.4.676-681.2000"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.6.2400-2407.1993"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400915"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.6.2780-2786.2002"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2008.070111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:57:56Z","timestamp":1760864276000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2008.070111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1902\/jop.2008.070111"],"URL":"https:\/\/doi.org\/10.1902\/jop.2008.070111","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}