{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:25:52Z","timestamp":1760919952112,"version":"build-2065373602"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of this study was to determine whether acute coronary syndrome (ACS) and angina patients have a greater prevalence of interleukin (IL)\u20101 polymorphism at the time of hospital admission than groups without ACS or angina.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A total of 106 patients hospitalized with ACS or angina were compared to a group of 1,959 individuals tested for susceptibility to periodontitis by profiling the IL\u20101 gene. Blood collected upon admission was analyzed by polymerase chain reaction amplification and gel electrophoresis to determine IL\u20101 polymorphism. A questionnaire was completed to assess home care and periodontal symptoms. Hospital and dental records were assessed for inclusion in the study, and dental records were analyzed for radiographic bone loss and dental history.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> ACS\/angina patients with severe radiographic bone loss demonstrated an increase in IL\u20101\u2013positive polymorphism (<jats:italic>P<\/jats:italic> = 0.06). If patients were \u226560 years of age, the prevalence of the positive gene was enriched (<jats:italic>P<\/jats:italic> = 0.009) with IL\u20101\u03b1+4845T increasing significantly (<jats:italic>P<\/jats:italic> = 0.015).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> For patients \u226560 years of age, there was a statistically significant correlation between ACS\/angina and IL\u20101 polymorphism. Patients with ACS or angina were more likely to evidence a positive IL\u20101 polymorphism and severe periodontitis.<\/jats:p>","DOI":"10.1902\/jop.2008.070206","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T09:29:20Z","timestamp":1199093360000},"page":"138-143","source":"Crossref","is-referenced-by-count":9,"title":["Presence and Significance of Interleukin\u20101 Polymorphism in Patients Who Present With Acute Coronary Syndrome, Angina, and Chronic Periodontitis: An Epidemiologic Pilot Study"],"prefix":"10.1002","volume":"79","author":[{"given":"David","family":"Goteiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ashmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Lehrman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malvin 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