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The degree of oral, periodontal, and systemic involvement determines the overall morbidity and, sometimes, the mortality of these disorders. We comprehensively review disorders commonly associated with DG and highlight diagnostic pathways, guidelines for differential diagnosis, and oral, periodontal, and systemic implications. More rare conditions are reviewed as well. Mucous membrane pemphigoid, oral lichen planus, and pemphigus vulgaris are responsible for the majority of cases of DG. In addition, other uncommon disorders should be considered. Accurate clinical, histologic, and serologic investigations are often required to differentiate among DG\u2010associated disorders, provide adequate therapy, and improve the prognosis of patients.<\/jats:p>","DOI":"10.1902\/jop.2008.070231","type":"journal-article","created":{"date-parts":[[2007,12,31]],"date-time":"2007-12-31T09:29:20Z","timestamp":1199093360000},"page":"4-24","source":"Crossref","is-referenced-by-count":81,"title":["Diagnostic Pathways and Clinical Significance of Desquamative Gingivitis"],"prefix":"10.1002","volume":"79","author":[{"given":"Lucio","family":"Lo 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