{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:23:34Z","timestamp":1789215814573,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Tissue\u2010engineered bone grafts represent an appealing alternative for maxillary sinus augmentation because they eliminate the significant drawbacks associated with extra\u2010 and intraoral bone\u2010harvesting procedures. In the present case series, we document the outcomes of sinus augmentation surgery using tissue\u2010engineered bone grafts.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Three patients requiring bilateral sinus augmentation received tissue\u2010engineered bone grafts combined with xenograft prior to implant placement. Implants were placed and loaded 6 and 12 months postaugmentation, respectively. Radiographs were taken and clinical examinations were performed preoperatively and at 4, 6, 12, and 18 months postaugmentation. Biopsies were obtained at 4 and 6 months postaugmentation. Standardized orthopantomograms were used to measure the posterior maxilla bone height.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> None of the patients experienced untoward complications during or following the therapeutic procedures. Ten implants were inserted into the augmented sinuses and loaded. Biopsies revealed a lack of inflammation or pathology; newly formed fibrous bone with osteoblastic activity and xenograft particles was evident. Compared to 4 months postaugmentation, augmented tissue was more mature at 6 months. The postoperative (18 months) bone height in augmented areas was significantly greater than the preoperative height (<jats:italic>P<\/jats:italic> &lt;0.0001), representing an \u223c4.5\u2010fold increase in bone height.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Sinus augmentation using tissue\u2010engineered bone grafts was successful in all three cases, permitting the subsequent insertion and loading of dental implants. The present cases demonstrated the feasibility of using engineered bone for sinus augmentation. Controlled clinical trials will be required to evaluate this new and evolving treatment modality.<\/jats:p>","DOI":"10.1902\/jop.2008.070255","type":"journal-article","created":{"date-parts":[[2008,3,3]],"date-time":"2008-03-03T09:21:35Z","timestamp":1204536095000},"page":"541-548","source":"Crossref","is-referenced-by-count":26,"title":["Use of Engineered Bone for Sinus Augmentation"],"prefix":"10.1002","volume":"79","author":[{"given":"Christian","family":"Beaumont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roswitha J.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris N.","family":"Tatakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory\u2010George","family":"Zafiropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130406.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02107-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020207.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80219-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.3.461"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-8532(22)02464-8"},{"key":"e_1_2_6_8_1","first-page":"11","article-title":"Report of the Sinus Consensus Conference of 1996","volume":"13","author":"Jensen OT","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2000.5.1.152"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-5182(02)00163-4"},{"key":"e_1_2_6_11_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?","volume":"22","author":"Aghaloo TL","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.04.024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1563\/1548-1336(2001)027<0194:ESRFAR>2.3.CO;2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(99)00280-X"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/02844310310007728"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(05)80286-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600601"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199903010-00003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2006.01295.x"}],"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2008.070255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:57:51Z","timestamp":1760864271000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2008.070255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1902\/jop.2008.070255"],"URL":"https:\/\/doi.org\/10.1902\/jop.2008.070255","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}