{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:56:26Z","timestamp":1769169386976,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present study was to investigate whether chronic periodontitis caused the elevated levels of anti\u2010cardiolipin antibodies (anti\u2010CL) and oxidized low\u2010density lipoprotein (oxLDL) in subjects with essential hypertension.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventy\u2010two subjects were categorized as healthy controls, subjects with essential hypertension and periodontal health (healthy\u2010hypertension group), subjects with essential hypertension and gingivitis (gingivitis\u2010hypertension group), or subjects with essential hypertension and chronic periodontitis (periodontitis\u2010hypertension group). Individuals with essential hypertension who had been taking antihypertensive medication \u22652 years were included in the present study. The presence of supragingival plaque, bleeding on probing (BOP), probing depth (PD), and clinical attachment level were recorded, and blood samples were collected. Serum immunoglobulin M (IgM) and immunoglobulin G (IgG) anti\u2010CL and oxLDL levels were assessed by enzyme\u2010linked immunosorbent assay. For IgM and IgG anti\u2010CL assays, positive tests were defined as \u226515 IgM phospholipid units and \u226510 IgG phospholipid units, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The mean IgM anti\u2010CL level and the prevalence of subjects positive for IgM anti\u2010CL were significantly higher in the periodontitis\u2010hypertension group compared to the other groups (<jats:italic>P<\/jats:italic> = 0.001). No significant differences were observed in the mean IgG anti\u2010CL and oxLDL levels or in the number of subjects positive for IgG anti\u2010CL and positive for IgM or IgG anti\u2010CL among the study groups. The Pearson correlation analysis revealed positive correlations between IgM anti\u2010CL levels and supragingival plaque, BOP, and PD scores.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Chronic periodontitis might play a causal role in the elevated serum levels of anti\u2010CL antibodies in individuals with essential hypertension. These elevated anti\u2010CL levels that are due to chronic periodontitis might contribute to an increased risk for atherosclerosis in individuals with essential hypertension.<\/jats:p>","DOI":"10.1902\/jop.2008.070321","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T08:57:43Z","timestamp":1202201863000},"page":"332-340","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of Serum Anti\u2010Cardiolipin and Oxidized Low\u2010Density Lipoprotein Levels in Chronic Periodontitis Patients With Essential 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