{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:08:29Z","timestamp":1790694509573,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Peri\u2010implantitis is an inflammatory process caused by microorganisms affecting the tissues around an osseointegrated implant in function, resulting in a loss of supporting bone. Limited data exist regarding the treatment of peri\u2010implantitis. The aim of this study was to assess the clinical and microbiologic outcome of repeated local administration of minocycline microspheres, 1 mg, in cases of peri\u2010implantitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010two subjects with at least one implant with a probing depth \u22654 mm combined with bleeding and\/or exudate on probing and the presence of putative pathogenic bacteria were included in the study. At baseline, subjects were randomly assigned to receive local minocycline microspheres (17 subjects and 57 implants) or chlorhexidine gel (15 subjects and 38 implants) following debridement. Treatments were performed on three occasions: baseline and days 30 and 90. Follow\u2010up examinations were conducted at 10 days and at 1, 3, 6, 9, and 12 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The use of minocycline resulted in significant improvements in probing depths compared to chlorhexidine at days 30, 90, and 180 (<jats:italic>P<\/jats:italic> = 0.5, <jats:italic>P<\/jats:italic> = 0.01, and <jats:italic>P<\/jats:italic> = 0.04, respectively). For the deepest sites of the minocycline\u2010treated implants, the mean probing depth reduction was 0.6 mm at 12 months. Regarding bleeding on probing, significant differences between groups, based on all four sites at the implants, were found at days 30, 90, 180, 270, and 360. Both treatments resulted in a marked reduction in the indicator bacteria.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The use of a repeated local antibiotic as an adjunct to the mechanical treatment of peri\u2010implantitis lesions demonstrated improvements in probing depths that were significantly different from controls and were sustained for 6 months. The adjunctive use of minocycline microspheres is beneficial in the treatment of peri\u2010implant lesions, but the treatment may have to be repeated.<\/jats:p>","DOI":"10.1902\/jop.2008.070347","type":"journal-article","created":{"date-parts":[[2008,5,3]],"date-time":"2008-05-03T22:06:45Z","timestamp":1209852405000},"page":"836-844","source":"Crossref","is-referenced-by-count":135,"title":["Mechanical and Repeated Antimicrobial Therapy Using a Local Drug Delivery System in the Treatment of Peri\u2010Implantitis: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"79","author":[{"given":"Stefan","family":"Renvert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lessem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Renvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Lindahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"365","volume-title":"Consensus report of session IV","author":"Albrektsson T","year":"1994"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.12.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01137.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00906.x"},{"key":"e_1_2_7_6_1","first-page":"32","article-title":"The clinical, microbial, and host response characteristics of the failing implant","volume":"12","author":"Salcetti JM","year":"1997","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1998.tb00124.x"},{"key":"e_1_2_7_8_1","first-page":"829","article-title":"Microbiota around root\u2010formed endosseous implants: A review of the literature","volume":"17","author":"Heydenrijk K","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130101.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00296.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280107.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.13.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2005.01141.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1997.2.1.343"},{"key":"e_1_2_7_15_1","first-page":"9","article-title":"Infections at osseointegrated implants \u2013Background and clinical implications (in German)","volume":"1","author":"Flemmig TF","year":"1994","journal-title":"Implantologie"},{"key":"e_1_2_7_16_1","first-page":"872","article-title":"Diagnosis and management of peri\u2010implant disease","volume":"25","author":"Kao RT","year":"1997","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.10.1118"},{"key":"e_1_2_7_18_1","first-page":"154","article-title":"Treatment of incipient peri\u2010implant infections using topical minocycline microspheres versus topical chlorhexidine gel as an adjunct to mechanical debridement","volume":"6","author":"Renvert S","year":"2004","journal-title":"J Int Acad Periodontol"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00919.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.10.1415"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1992.030402.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2001.012004287.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.08.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2004.06.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1535"},{"key":"e_1_2_7_26_1","first-page":"77","article-title":"Scaling and root\u2010planing treatment with adjunctive subgingival minocycline. 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