{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T23:36:06Z","timestamp":1789947366723,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Herpesviruses may be related to the etiology of aggressive periodontitis (AgP) and chronic periodontitis (CP) by triggering periodontal destruction or by increasing the risk for bacterial infection. This case\u2010control study evaluated the presence of herpes simplex virus type I (HSV\u20101), Epstein\u2010Barr virus type I (EBV\u20101), human cytomegalovirus (HCMV), <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (previously <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>), <jats:italic>Porphyromonas gingivalis<\/jats:italic>, <jats:italic>Prevotella intermedia<\/jats:italic>, and <jats:italic>Tannerella forsythia<\/jats:italic> (previously <jats:italic>T. forsythensis<\/jats:italic>) in patients with generalized AgP (AgP group), CP (CP group), or gingivitis (G group) and in healthy individuals (C group).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Subgingival plaque samples were collected with paper points from 30 patients in each group. The nested polymerase chain reaction (PCR) method was used to detect HSV\u20101, EBV\u20101, and HCMV. Bacteria were identified by 16S rRNA\u2010based PCR.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> HSV\u20101, HCMV, and EBV\u20101 were detected in 86.7%, 46.7%, and 33.3% of the AgP group, respectively; in 40.0%, 50.0%, and 46.7% of the CP group, respectively; in 53.3%, 40.0%, and 20.0% of the G group, respectively; and in 20.0%, 56.7%, and 0.0% of the C group, respectively. <jats:italic>A. actinomycetemcomitans<\/jats:italic> was detected significantly more often in the AgP group compared to the other groups (<jats:italic>P<\/jats:italic> &lt;0.005). <jats:italic>P. gingivalis<\/jats:italic> and <jats:italic>T. forsythia<\/jats:italic> were identified more frequently in AgP and CP groups, and AgP, CP, and G groups had higher frequencies of <jats:italic>P. intermedia<\/jats:italic> compared to the C group.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In Brazilian patients, HSV\u20101 and EBV\u20101, rather than HCMV, were more frequently associated with CP and AgP.<\/jats:p>","DOI":"10.1902\/jop.2008.070388","type":"journal-article","created":{"date-parts":[[2008,12,4]],"date-time":"2008-12-04T07:12:25Z","timestamp":1228374745000},"page":"2313-2321","source":"Crossref","is-referenced-by-count":72,"title":["Detection of Herpesviruses and Periodontal Pathogens in Subgingival Plaque of Patients With Chronic Periodontitis, Generalized Aggressive Periodontitis, or Gingivitis"],"prefix":"10.1002","volume":"79","author":[{"given":"Ana Vit\u00f3ria","family":"Imbronito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osmar Shizuo","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivea","family":"Maria de Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Fraga","family":"Moreira 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