{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:59:45Z","timestamp":1761058785351,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Tuberous sclerosis is an autosomal\u2010dominant inherited disease involving many organs of the body. Oral manifestations include gingival enlargement, fibromas, and dental enamel pitting. The report presents a case of tuberous sclerosis with gingival enlargement histologically consistent with angiofibroma, describes its successful periodontal management, and reviews the literature associated with oral manifestations of tuberous sclerosis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A 26\u2010year\u2010old white male presented to the Department of Periodontics and Implant Dentistry, New York University College of Dentistry, with a diagnosis of tuberous sclerosis and a chief complaint of gingival enlargement affecting mastication and esthetics. Following a complete medical history review, consultation with the patient's medical team at New York University Medical Center, and a thorough oral and periodontal examination, a treatment plan was developed that included oral hygiene instructions, mechanical debridement, and periodontal reevaluation. This was followed by gingivectomy, which provided improved function and esthetics. Excised tissue was submitted for histologic examination. The patient was followed every 2 months for assessment of the outcome of the surgical treatment. An extensive search of the dental and dermatologic literature was performed on MEDLINE.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Histologic examination of the gingival tissue revealed features consistent with angiofibroma. Fifteen months following gingivectomy, the contours and gingival surface appearance remained normal.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The gingival enlargement was histologically consistent with the characteristic angiofibromas of tuberous sclerosis. The gingival enlargement responded very well to gingivectomy and periodontal maintenance.<\/jats:p>","DOI":"10.1902\/jop.2008.070407","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T08:57:21Z","timestamp":1207040241000},"page":"759-763","source":"Crossref","is-referenced-by-count":12,"title":["Gingival Enlargement as a Manifestation of Tuberous Sclerosis: Case Report and Periodontal Management"],"prefix":"10.1002","volume":"79","author":[{"given":"Urszula B.","family":"Korol","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veena","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Almas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan A.","family":"Phelan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511545054"},{"key":"e_1_2_6_3_1","first-page":"410","volume-title":"Syndromes of the Head and Neck","author":"Gorlin RJ","year":"1990"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"A heart of the newborn child exhibiting tumors in the walls of heart cavities (in German)","volume":"20","author":"Von Recklinghausen F","year":"1862","journal-title":"Monatschr Gegurtsk"},{"key":"e_1_2_6_5_1","first-page":"81","article-title":"Cerebral symptoms of tuberous sclerosis: Mental retardation and hemiplegic epilepsy","volume":"1","author":"Bourneville DM","year":"1880","journal-title":"Arch Neurol"},{"key":"e_1_2_6_6_1","first-page":"1","article-title":"A case of congenital adenoma sebaceum","volume":"890","author":"Pringle JJ","year":"1901","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_7_1","first-page":"106","article-title":"Zur About pathology and pathologic anatomy of various idiotic forms (types). 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