{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:55:31Z","timestamp":1767916531201,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Regenerative periodontal therapy using platelet\u2010rich plasma (PRP) and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to enhance the outcome of regenerative surgery. However, there are limited data from controlled clinical studies evaluating the effect of PRP on the healing of deep intrabony defects treated with a combination of bone substitutes and GTR. The aim of this study was to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with beta tricalcium phosphate (\u03b2\u2010TCP) and GTR by means of a non\u2010bioresorbable expanded polytetrafluoroethylene membrane.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty\u2010eight subjects with advanced chronic periodontal disease and displaying one intrabony defect were treated randomly with a combination of PRP + \u03b2\u2010TCP + GTR or \u03b2\u2010TCP + GTR. Plaque index, gingival index, bleeding on probing, probing depth (PD), gingival recession, and clinical attachment level (CAL) were evaluated at baseline and at 1 year after treatment. CAL was the primary outcome variable.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all subjects. At 1 year after therapy, the sites treated with PRP + \u03b2\u2010TCP + GTR showed a reduction in mean PD from 9.1 \u00b1 0.6 mm to 3.3 \u00b1 0.5 mm (<jats:italic>P<\/jats:italic> &lt;0.001) and a change in mean CAL from 10.1 \u00b1 1.3 mm to 5.7 \u00b1 1.1 mm (<jats:italic>P<\/jats:italic> &lt;0.001). In the group treated with \u03b2\u2010TCP + GTR, mean PD was reduced from 9.0 \u00b1 0.8 mm to 3.6 \u00b1 0.9 mm (<jats:italic>P<\/jats:italic> &lt;0.001), and the mean CAL changed from 9.9 \u00b1 1.0 mm to 5.9 \u00b1 1.2 mm (<jats:italic>P<\/jats:italic> &lt;0.001). In both groups, all sites gained \u22653 mm of CAL. CAL gains \u22654 mm were noted in 86% (12 of 14 defects) of the cases treated with PRP + \u03b2\u2010TCP + GTR and in 79% (11 of 14 defects) of those treated with \u03b2\u2010TCP + GTR. No statistically significant differences in any of the investigated parameters were observed between the two groups at the 1\u2010year reevaluation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> At 1 year after surgery, both therapies resulted in significant PD reductions and CAL gains.<\/jats:p>","DOI":"10.1902\/jop.2008.070473","type":"journal-article","created":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T08:57:21Z","timestamp":1207040241000},"page":"660-669","source":"Crossref","is-referenced-by-count":63,"title":["Effect of Platelet\u2010Rich Plasma on the Healing of Intrabony Defects Treated With Beta Tricalcium Phosphate and Expanded Polytetrafluoroethylene Membranes"],"prefix":"10.1002","volume":"79","author":[{"given":"Ferenc","family":"D\u00f6ri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam\u00e1s","family":"Husz\u00e1r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Nikolidakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora","family":"Tihanyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Horv\u00e1th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole B.","family":"Arweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Gera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"650","volume-title":"Regenerative periodontal therapy","author":"Karring T","year":"2003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00208.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.12.1158"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb02334.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.7.458"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1992.tb01679.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00403.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.5.429"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.12.1186"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.12.2205"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(98)90029-4"},{"key":"e_1_2_7_13_1","first-page":"664","article-title":"Platelet\u2010rich plasma: A promising innovation in dentistry","volume":"69","author":"T\u00f6z\u00fcm TF","year":"2003","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_7_14_1","first-page":"93","article-title":"Is platelet\u2010rich plasma the perfect enhancement factor? 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