{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:28:30Z","timestamp":1790195310315,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study was to evaluate the clinical and laboratory changes 3 months after full\u2010mouth scaling and root planing in subjects with and without diabetes mellitus.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> This study was performed using 10 subjects with type 2 diabetes mellitus who required insulin therapy (DM) and 10 healthy adult control subjects (NDM) with generalized chronic periodontal disease. Both groups were treated with full\u2010mouth scaling and root planing and given oral hygiene instructions. Clinical parameters, including plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), and clinical attachment level (CAL), were measured at four sites per tooth. Subgingival plaque samples were obtained from sites with the deepest PD (\u22655 mm) and with furcations in each subject. Samples were also tested for the presence of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (previously <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>), <jats:italic>Porphyromonas gingivalis<\/jats:italic>, and <jats:italic>Tannerella forsythia<\/jats:italic> (previously <jats:italic>T. forsythensis<\/jats:italic>) by polymerase chain reaction. Glycemic control (glycosylated hemoglobin [HbA1c] and fasting glucose levels) and clinical and microbiologic assessments were recorded at baseline and 3 months after periodontal treatment.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Data revealed statistical changes (<jats:italic>P<\/jats:italic> \u22640.05; analysis of variance [ANOVA]) in clinical variables (PI, GI, PD, GR, and CAL) between baseline and 3 months in both groups. Conversely, no improvement in the fasting glucose level or glycosylated hemoglobin (<jats:italic>P<\/jats:italic> \u22640.05; ANOVA) was found after treatment. Besides some reduction in the bacterial frequency 3 months after treatment, no statistically significant difference was found between the groups.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Clinical and laboratory responses were similar in DM and NDM groups 3 months after full\u2010mouth scaling and root planing.<\/jats:p>","DOI":"10.1902\/jop.2008.070503","type":"journal-article","created":{"date-parts":[[2008,7,2]],"date-time":"2008-07-02T08:54:28Z","timestamp":1214988868000},"page":"1150-1157","source":"Crossref","is-referenced-by-count":67,"title":["Clinical and Laboratory Evaluations of Non\u2010Surgical Periodontal Treatment in Subjects With Diabetes Mellitus"],"prefix":"10.1002","volume":"79","author":[{"given":"Gabriela Alessandra da","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"de Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enilson Antonio","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Wilson","family":"Sallum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucia Maria Bovi","family":"Ambrosano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina","family":"de C\u00e1ssia Orlandi Sardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio Eduardo Braga da","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo Bruno","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2337\/diacare.29.s1.06.s43","article-title":"Position statement. 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