{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:23:40Z","timestamp":1789215820746,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17390558"],"award-info":[{"award-number":["17390558"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of the present controlled clinical study was to compare the clinical response of human cultured periosteum (HCP) sheets in combination with platelet\u2010rich plasma (PRP) and porous hydroxyapatite (HA) granules to a mixture of PRP and HA in the treatment of human infrabony periodontal defects.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty interproximal infrabony osseous defects in 30 healthy, non\u2010smoking subjects diagnosed with chronic periodontitis were included in this study. The subjects were randomly assigned to the test group (HCP sheets combined with PRP and HA) or the control group (PRP with HA). Clinical and radiographic measurements were made at baseline and the 12\u2010month post\u2010surgical evaluation.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Compared to baseline, the 12\u2010month results indicated that both treatment modalities resulted in statistically significant changes (<jats:italic>P<\/jats:italic> &lt;0.01) in the gingival index, bleeding on probing, probing depth, clinical attachment level, and radiographic infrabony defect depth. Compared to the control group, the test group exhibited a statistically significantly more favorable change in clinical attachment gain (3.9 \u00b1 1.6 mm versus 2.7 \u00b1 1.3 mm; <jats:italic>P<\/jats:italic> &lt;0.05), vertical relative attachment gain (83.5% \u00b1 31.7% versus 55.0% \u00b1 21.9%; <jats:italic>P<\/jats:italic> &lt;0.05), and radiographic infrabony defect fill (4.9 \u00b1 1.2 mm versus 3.2 \u00b1 1.1 mm; <jats:italic>P<\/jats:italic> &lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Compared to PRP with HA, treatment with a combination of HCP sheets, PRP, and HA led to a significantly more favorable clinical improvement in infrabony periodontal defects. A factor likely contributing to these favorable clinical results is the presence of osteogenic cells in the HCP sheets, which provided greater regeneration potential.<\/jats:p>","DOI":"10.1902\/jop.2008.070518","type":"journal-article","created":{"date-parts":[[2008,5,3]],"date-time":"2008-05-03T22:06:45Z","timestamp":1209852405000},"page":"811-818","source":"Crossref","is-referenced-by-count":93,"title":["Tissue\u2010Engineered Cultured Periosteum Used With Platelet\u2010Rich Plasma and Hydroxyapatite in Treating Human Osseous Defects"],"prefix":"10.1002","volume":"79","author":[{"given":"Kanoko","family":"Yamamiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken\u2010ichiro","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry F.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"213","article-title":"Periodontal regeneration in 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