{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:46:38Z","timestamp":1790815598431,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The preservation of bone volume immediately after tooth removal might be necessary to optimize the success of implant placement in terms of esthetics and function. The objectives of this randomized clinical trial were two\u2010fold: 1) to compare the bone dimensional changes following tooth extraction with extraction plus ridge preservation using corticocancellous porcine bone and a collagen membrane; and 2) to analyze and compare histologic and histomorphometric aspects of the extraction\u2010alone sites to the grafted sites.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Forty subjects who required tooth extraction and implant placement were enrolled in this study. Using a computer\u2010generated randomization list, the subjects were randomly assigned to the control group (EXT; extraction alone) or to the test group (RP; ridge\u2010preservation procedure with corticocancellous porcine bone and collagen membrane). The following parameters were assessed immediately after extraction and 7 months prior to implant placement: plaque index, gingival index, bleeding on probing, horizontal ridge width, and vertical ridge changes. A bone biopsy was taken from the control and test sites 7 months after the surgical treatment. Histologic and histomorphometric analyses were also performed.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A significantly greater horizontal reabsorption was observed at EXT sites (4.3 \u00b1 0.8 mm) compared to RP sites (2.5 \u00b1 1.2 mm). The ridge height reduction at the buccal side was 3.6 \u00b1 1.5 mm for the extraction\u2010alone group, whereas it was 0.7 \u00b1 1.4 mm for the ridge\u2010preservation group. Moreover, the vertical change at the lingual sites was 0.4 mm in the ridge\u2010preservation group and 3 mm in the extraction\u2010alone group. Forty biopsies were harvested from the experimental sites (test and control sites). The biopsies harvested from the grafted sites revealed the presence of trabecular bone, which was highly mineralized and well structured. Particles of the grafted material could be identified in all samples. The bone formed in the control sites was also well structured with a minor percentage of mineralized bone. The amount of connective tissue was significantly higher in the extraction\u2010alone group than in the ridge\u2010preservation group.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The ridge\u2010preservation approach using porcine bone in combination with collagen membrane significantly limited the resorption of hard tissue ridge after tooth extraction compared to extraction alone. Furthermore, the histologic analysis showed a significantly higher percentage of trabecular bone and total mineralized tissue in ridge\u2010preservation sites compared to extraction\u2010alone sites 7 months after tooth removal.<\/jats:p>","DOI":"10.1902\/jop.2008.070628","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T12:56:43Z","timestamp":1217595403000},"page":"1370-1377","source":"Crossref","is-referenced-by-count":274,"title":["Xenograft Versus Extraction Alone for Ridge Preservation After Tooth Removal: A Clinical and Histomorphometric Study"],"prefix":"10.1002","volume":"79","author":[{"given":"Antonio","family":"Barone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2 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