{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:12:31Z","timestamp":1767651151944,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The purpose of the present study was the clinical and the histologic evaluation of fresh frozen human bone (FFB) allografts used for maxillary sinus\u2010augmentation procedures.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Ten subjects were treated with maxillary sinus augmentations using FFB. Radiologic measurements were recorded on computed tomography scans preoperatively and 5 months after the sinus surgeries. At 5 months, during implant placement, 10 core biopsies were retrieved and processed for histomorphometric evaluation under light microscopy (LM). Clinical and histomorphometric measurements are presented as mean \u00b1 SD.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> At baseline, the height of the alveolar ridge measured 4.3 \u00b1 1.3 mm (mean); after augmentation procedures, at implant positioning, it had a mean height of 16.0 \u00b1 1.8 mm. All 22 dental implants were clinically healthy after 5 months. LM showed that most of the specimens presented newly formed bone that was completely integrated with preexisting bone. The interface areas between new and old bone were not discernible. Woven bone was present in some areas of the biopsies; however, in the majority of the examined regions, there was mature osseous tissue presenting features of trabecular bone. There was no evidence of an acute inflammatory infiltrate. Histomorphometry revealed that the percentage of bone was 48.15% \u00b1 14.32%, whereas marrow spaces occupied the rest of the area.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> FFB is a biocompatible material that can be successfully used for maxillary sinus augmentations without interfering with normal reparative bone processes.<\/jats:p>","DOI":"10.1902\/jop.2008.070649","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T20:03:05Z","timestamp":1220558585000},"page":"1789-1796","source":"Crossref","is-referenced-by-count":27,"title":["Clinical, Histologic, and Histomorphometric Analyses of Regenerated Bone in Maxillary Sinus Augmentation Using Fresh Frozen Human Bone Allografts"],"prefix":"10.1002","volume":"79","author":[{"given":"Claudio","family":"Stacchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Orsini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Di Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Breschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Di Lenarda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"528","article-title":"Sinus floor elevation using anorganic bovine bone matrix (OsteoGraf\/N) with and without autogenous bone: A clinical, histologic, radiographic, and histomorphometric analysis \u2013 Part 2 of an ongoing prospective study","volume":"18","author":"Froum SJ","year":"1998","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_3_1","first-page":"232","article-title":"Maxillary sinus floor elevation for implant placement with demineralized freeze\u2010dried bone and bovine bone (Bio\u2010Oss): A clinical study of 20 patients","volume":"17","author":"Valentini P","year":"1997","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1998.090108.x"},{"key":"e_1_2_7_5_1","first-page":"15","article-title":"Biomaterials and biomechanics of oral and maxillofacial implants: Current status and future developments","volume":"15","author":"Brunski JB","year":"2000","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1996.090608.x"},{"key":"e_1_2_7_7_1","first-page":"11","article-title":"Report of the Sinus Consensus Conference of 1996","volume":"13","author":"Jensen OT","year":"1998","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.2002.130411.x"},{"key":"e_1_2_7_9_1","first-page":"635","article-title":"A clinical and histologic evaluation of implant integration in the posterior maxilla after sinus floor augmentation with autogenous bone, bovine hydroxyapatite, or a 20:80 mixture","volume":"17","author":"Hallman M","year":"2002","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.328"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000220120.54308.f3"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.060181"},{"key":"e_1_2_7_13_1","first-page":"249","article-title":"Systematic review of survival rates for immediately loaded dental implants","volume":"26","author":"Del Fabbro M","year":"2006","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_7_14_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?","volume":"22","author":"Aghaloo T","year":"2007","journal-title":"Int J Oral Maxillofac Implants"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/000164700317413094"},{"key":"e_1_2_7_16_1","first-page":"41","article-title":"Bone graft incorporation after reconstruction of bony defects with impacted morselized bone graft. 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